Results 81 to 90 of about 13,693,867 (238)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Estimation of Dose-Response Functions and Optimal Doses with a Continuous Treatment [PDF]

This paper considers the continuous-treatment case and develops nonparametric estimators for the average dose-response function, the treatment level at which this function is maximized (location of the maximum), and the maximum value achieved by this ...
Carlos A. Flores
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Size‐specific dose estimates calculated using patient size measurements from scanned projection radiograph in high‐resolution chest computed tomography

Journal of Medical Radiation Sciences
Introduction Size‐specific dose estimates (SSDE) are used to assess patient‐specific radiation exposure in Computed Tomography (CT), complementing the volume CT dose index (CTDIvol).
Ajit Brindhaban
doaj   +1 more source

Relationship between Water-equivalent Diameter, Computed Tomography Dose Indices, and Image Noise in Pediatric Head Computed Tomography Under Active and Inactive Tube Current Modulation

Journal of Medical Physics
Purpose: This study investigated the relationships among water-equivalent diameter (Dw), volume computed tomography dose index (CTDIvol), size-specific dose estimate (SSDE), and image noise in pediatric head computed tomography (CT) under active and ...
Evi Setiawati, Choirul Anam, Bella Diani Safitri, Much Azam, Qidir Maulana Binu Soesanto, Agus Margiantono   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Towards prospective identification of optimal scan parameters for CT-guided interventions: a phantom study

Scientific Reports
CT-guided interventions require balance between radiation dose and image quality. This study evaluates the impact of tube voltage and tube load on the contrast-to-noise ratio (CNR) across different patient sizes and target tissues. A modular multi-energy
Constantin Schareck, Neele Blumhoff, Malte M. Sieren, Roman Kloeckner, Franz Wegner   +4 more
doaj   +1 more source

Appraisal of radiation dose with 64-slice computed tomography perfusion in lung cancer patients with special reference to SSDE: An initial experience in a tertiary care hospital

Indian Journal of Radiology and Imaging, 2017
Context: Computed tomography perfusion (CTP) is an important functional tool for lung cancer. It is expected to deliver high radiation dose, making its accurate estimation important. Size-specific dose estimate (SSDE) is a new dose metric, which includes
Shuchi Bhatt, Ajai K Srivastava, Neha Meena, Shweta Thakur   +3 more
doaj   +1 more source