Results 91 to 100 of about 20,472 (183)

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

International Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta, Jaspreet Kaur, Amanda Liddy, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Profiles of peripheral B cell subsets in a cohort of primary Sjögren's syndrome patients and their potential clinical significance

Journal of Dental Sciences
Background/purpose: Primary Sjögren's syndrome is a prototypical autoimmune disease, with B cell dysfunction as a dominant feature. Further insights into distribution of B cell subsets in primary Sjögren's syndrome are urgently required to identify the ...
Yixiao Xing, Boya Li, Pan Wei, Hong Hua
doaj   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, EarlyView.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Efficacy and safety of high doses of eltrombopag for treating adult immune thrombocytopenia: Results from a multicentre retrospective cohort study

British Journal of Haematology, EarlyView.
Salomé Dahan, Stéphanie Guillet, Olivier Fain, Delphine Gobert, Stéphane Cheze, Florent Broca, Bertrand Godeau, Marc Michel   +7 more
wiley   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Sjögren's Syndrome With Distal Renal Tubular Acidosis and Hypokalemic Myopathy in Pregnancy: A Rare Case

Clinical Case Reports
Sjogren's syndrome may rarely present with distal renal tubular acidosis (dRTA), causing severe hypokalemia and myopathy. A 27‐year‐old primigravida at 15 weeks gestation presented with progressive proximal weakness and myalgia.
Nabiha Khan, Aasim Ali, Sadia Khan, Uzka Ghayour, Dipesh Kumar Yadav, Armaghana Abdullah   +5 more
doaj   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Sjögren’s syndrome and hepatitis C virus infection presenting as hypokalemic quadriparesis: A case report

Journal of International Medical Research
Distal renal tubular acidosis can present with acute-onset quadriparesis caused by severe hypokalemia, and primary Sjögren’s syndrome is a significant potential cause of distal renal tubular acidosis in such patients.
Ashish Joshi, Ujjwol Prasad Risal, Navin Kumar Sah, Bhupendra Shah   +3 more
doaj   +1 more source

Placental malperfusion and angiogenesis‐related proteins are associated with small‐for‐gestational‐age in systemic lupus erythematosus

Journal of Internal Medicine, EarlyView.
Abstract Background Although systemic lupus erythematosus (SLE) pregnancy frequently results in small for gestational age (SGA) infants, the understanding of underlying mechanisms is limited. We aimed to identify specific histological patterns of placental injury in SGA in SLE and to explore whether an altered balance of angiogenesis‐related proteins ...
Marit Stockfelt, Henri Puttonen, Ing‐Marie Fyhr, Agnes Torell, Kerstin Andersson, Iva Gunnarsson, Elisabet Svenungsson, Agneta Zickert, Maria Majczuk Sennström, Estelle Trysberg, Anders A. Bengtsson, Andreas Jönsen, Helena Strevens, Christopher Sjöwall, Muna Saleh, Sofia Pihl, Dag Leonard, Lars Rönnblom, Tansim Akhter, Bo Jacobsson, Anna‐Carin Lundell, Anna Rudin   +21 more
wiley   +1 more source