Results 41 to 50 of about 38,700 (229)

Síndrome seco - Síndrome de Sjögren

, 2002
¿Qué es el "síndrome seco"?/ ¿Qué es el síndrome Sjögren?/ ¿Qué es un síndrome de Sjögren primario y qué es un síndrome de Sjögren secundario?/ ¿Cuáles son las causas del síndrome de Sjögren?/ ¿Qué otras manifestaciones distintas a los síntomas secos ...
Cañas Dávila, Carlos Alberto
core   +2 more sources

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Optical coherence tomography angiography to assess for retinal vascular changes in Neuro-Sjögren

Therapeutic Advances in Ophthalmology
Background: Sjögren’s syndrome is an autoimmune disease characterized by sicca symptoms and various extraglandular manifestations including vasculitis. Neurological involvement occurs frequently (Neuro-Sjögren) and often mimics immune neuropathies such ...
Melanie Haar, Franz Felix Konen, Marten A. Gehlhaar, Irene Oluwatoba-Popoola, Emilia Donicova, Marija Wachsmann, Ahmed Lubbad, Katerina Hufendiek, Amelie Pielen, Bettina Hohberger, Christian Mardin, Stefan Gingele, Nils K. Prenzler, Diana Ernst, Torsten Witte, Carsten Framme, Thomas Skripuletz, Tabea Seeliger, Anna Bajor   +18 more
doaj   +1 more source

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

Grammatik und Wörterverzeichnis. Mit einem Anhang zu den salis-livischen Sprichwörtern. Auf der Grundlage von J. A. Sjögrens Sprachmaterialien verfasst von Eberhard Winkler und Karl Pajusalu

, 2018
Das Livland- oder Salis-Livische, die im 19. Jahrhundert untergegangene Schwestersprache des Livischen in Kurland (Lettland), ist im Wesentlichen durch die Sprachbeispiele Johann Andreas Sjögrens bekannt.
Sjögren, Andreas Johan, Winkler, Eberhard, Pajusalu, Karl   +2 more
core   +1 more source

PRİMER SJÖGREN SENDROMUNDA SEROLOJİK TETKİKLERİN TÜKRÜK BEZİ BİYOPSİ DERECESİ VE KLİNİK İLİŞKİSİNİN DEĞERLENDİRİLMESİ

Journal of Contemporary Medicine, 2019
Giriş-Amaç: Sjögrensendromu göz yaşı ve tükrük bezleri olmak üzere tüm ekzokrin bezleri etkileyen kronik,sistemik otoimmün bir hastalıktır. Sjögren sendromu tanısında klinik ve seroimmünolojiktestlerden faydalanılır.
Muhammet Limon, Dilek Tezcan, Semral Gülcemal, Sema Yılmaz, Neriman Akdam   +4 more
doaj   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Longing for the Past: An Analysis of Discursive Formations in the Greta Thunberg Message

Culture Unbound: Journal of Current Cultural Research, 2020
This article studies discursive formations of climate change in texts by the contemporary climate activist movement’s most famous character, Greta Thunberg.
Hanna Sjögren
doaj   +1 more source