Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu +7 more
wiley +1 more source
On the boundary convergence of solutions to the Hermite-Schr\"odinger equation
In the half-space $\mathbb{R}^d \times \mathbb{R}_+$, we consider the Hermite-Schr\"odinger equation $i\partial u/\partial t = - \Delta u + |x|^2 u$, with given boundary values on $\mathbb{R}^d$.
Sjögren, Peter, Torrea, J. L.
core +1 more source
Role of M3 Muscarinic Acethylcholine Receptor Antibodies as a New Marker in Primary Sjögren Syndrome [PDF]
Aims: This paper investigates the presence of M3 muscarinic acetylcholine receptor autoantibody present in the serum of patients with primary Sjögren syndrome (pSS).
Borda, Enri Santiago +4 more
core +1 more source
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
Sjögren syndrome complicated by acute lymphoblastic leukemia
Malignant lymphoma is a well-recognized occurrence in Sjögren syndrome; however, progression to acute lymphoblastic leukemia is extremely uncommon. Here we present a patient with Sjögren syndrome complicated with acute lymphoblastic leukemia.
Fariba Binesh +4 more
doaj
Paralisia Por Hipocaliémia: Manifestação Inaugural da Síndrome de Sjögren Primário
O Síndrome de Sjögren é uma doença auto-imune sistémica caracterizada por inflamação crónica das glândulas exócrinas. As manifestações extraglandulares têm uma incidência até 25%.
Aurélia L Martinho +2 more
doaj +1 more source
Analysis of the pathogenic factors and management of dry eye in ocular surface disorders [PDF]
The tear film represents the interface between the eye and the environment. The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome. Despite having a multifactorial origin,
Albietz +14 more
core +1 more source
IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model [PDF]
PURPOSE. While the association between the gut microbiome and the immune system has been studied in autoimmune disorders, little is known about ocular disease.
Choi, Se Hyun +6 more
core +1 more source
Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu +6 more
wiley +1 more source
Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko +9 more
wiley +1 more source

