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Multi‐Parametric Magnetic Resonance Imaging to Assess Empagliflozin Effect on the Kidneys in People With Type 2 Diabetes Mellitus: A Pilot Clinical Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Empagliflozin is renoprotective in Type 2 diabetes mellitus (T2DM). Our primary aim was to assess empagliflozin's effect on glomerular filtration rate and renal vascular resistance using multiparametric MRI (MpMRI). Our secondary aim was to assess the impact of empagliflozin on additional MpMRI‐derived metrics including markers of tissue ...
Ruth P. Lim +9 more
wiley +1 more source

系统性红斑狼疮患者血浆可溶性血栓调节蛋白的动态观察附视频

Zhongguo shiyan zhenduanxue, 2000
目的　了解血浆可溶性血栓调节蛋白（ｓＴＭ）与系统性红斑狼疮（ＳＬＥ）活动度的关系。方法ＥＬＩＳＡ法测定４６例ＳＬＥ患者及２０例正常人血浆ｓＴＭ水平，观察１９例ＳＬＥ患者治疗前后血浆ｓＴＭ变化情况。结果ＳＬＥ活动组ｓＴＭ水平高于非活动组和对照组（Ｐ＜０．０１）；ｓＴＭ与多个ＳＬＥ活动度评分相关（Ｐ＜０．００１）；治疗后ｓＪＭ水平显著降低（Ｐ＜０．０１）。结论血浆ｓＴＭ水平与ＳＬＥ活动度相关，可作为ＳＬＥ的疗效观察指标。
石菁华 +5 more
doaj

New insights and novel perspectives in bileaflet mechanical heart valve prostheses thromboresistance

Journal of Cardiothoracic Surgery
Background Although well-known for their thromboresistance, bileaflet mechanical heart valves (BMHV) require lifelong anti-thrombotic therapy. This must be associated with a certain level of thrombogenicity.
Giorgio Vigano +4 more
doaj +1 more source

Nutritional composition of pollen stores in managed bees across European agro‐ecosystems reveals species‐specific differences but limited pesticide effects

Ecological Entomology, EarlyView.
In the pollen stores of three bee species deployed across 128 European sites, bumble bees harboured lower lipid content and higher protein‐to‐lipid ratios than honey bees and mason bees. Toxicity‐weighted pesticide risk did not alter protein‐to‐lipid ratios, but higher risk was associated with reduced protein and lipid content in the pollen stores of ...
Antoine Gekière +34 more
wiley +1 more source

Impact of Evidence‐Based Dentistry Education on Dental Students' Critical Appraisal Skills: A Prospective Cohort Study

European Journal of Dental Education, EarlyView.
ABSTRACT Objective This study aimed to assess the impact of evidence‐based dentistry (EBD) education on the critical appraisal abilities of dental students. Methods A prospective cohort study was conducted with students from the Faculty of Dental Medicine in Lisbon.
Carlota Inês Duarte de Mendonça +5 more
wiley +1 more source

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht +6 more
wiley +1 more source

Projekt Slovensko javno mnenje in njegov čas SJM 1968-1999

, 1999
V prvem delu avtor prikazuje zasnovo in rast projekta Slovensko javno mnenje (SJM) v obdobju 1968-1999. Projekt SJM označi kot nacionalni družboslovni empirični infrastrukturni projekt, ki je potekal in se razvijal sočasno s podobnimi infrastrukturnimi projekti v ameriškem in zahodnoevropskem družboslovju (npr. General Social Survey, Allbus).
openaire +2 more sources

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source

Using Eye Lens Stable Isotopes to Identify the Rearing Origin of Fall Age‐0 Walleye (Sander vitreus)

Fisheries Management and Ecology, EarlyView.
ABSTRACT Isotope values in fish eye lenses may be useful in differentiating rearing origins. We compared eye lens isotopic values of fall fingerling age‐0 walleye (Sander vitreus) reared in a hatchery pond, a recirculating aquaculture system (RAS), and a natural lake. Using 10 fish per rearing source, we delaminated layers from one eye lens per fish to
Justin M. Sturtz +5 more
wiley +1 more source

Hodgkin and non‐Hodgkin lymphomas in the post‐antiretroviral therapy era according to HIV virological suppression

HIV Medicine, EarlyView.
Abstract Objectives Lymphomas remain among the most frequent HIV‐associated malignancies, with risk persisting despite effective virological control. This study describes the clinical, epidemiological and prognostic characteristics of lymphomas (both Hodgkin [HL] and non‐Hodgkin [NHL]) in people living with HIV (PLWH), according to virological ...
Teresa Aldámiz‐Echevarria +555 more
wiley +1 more source

heart valve prosthesis
humans
middle aged

female
male
aortic valve

3. good health
follow-up studies
aortic valve replacement