Results 51 to 60 of about 18,718 (235)

Sjogren’s Syndrome: A Review

Journal of Indian Academy of Oral Medicine and Radiology, 2011
Sjogren′s syndrome, also known as "Mikulicz disease" or "Sicca syndrome" is a systemic autoimmune disease in which immune cells attack and destroy the exocrine glands that produce tears and saliva. It can exist by itself (primary Sjogren syndrome) or develop in association with another disorder such as rheumatoid arthritis, systemic sclerosis, primary ...
Rani Somani, M K Sunil, Jaskirat Khaira, Dilip Kumar   +3 more
openaire   +2 more sources

Association of Childhood Acute Leukemia With Autoimmune Diseases

International Journal of Cancer, EarlyView.
A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka, Julia Ventelä, Anssi Auvinen, Olli Lohi, Atte Nikkilä   +4 more
wiley   +1 more source

Efficacy of Cevimeline on Xerostomia in Sjögren's Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Current Therapeutic Research
Background: Xerostomia, or dry mouth, is a common and debilitating symptom in patients with Sjögren's syndrome, affecting their quality of life. Although Cevimeline, a muscarinic agonist, has been investigated as a potential treatment, its efficacy and ...
Mehdi Karimi, MD, Fatemeh Ahmadi Hajikolaei, MD, Fahime Hoseinpour, MD, Seyed-Ali Hashemi, MD, Anita Fatehi, MD, Seyed-Abbas Pakmehr, MD, Niloofar Deravi, MD, Mahdyieh Naziri, MSc, Mohaddeseh Belbasi, MD, Sahar Khoshravesh, MD, Seyed Hossein Vaezzadeh, MD   +10 more
doaj   +1 more source

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver, Steven Haworth, Evan Graumann, Bradie Frizzell, David H. Lee, Jiwoong Choi, Chase S. Hall, Scott M. Matson, Mark Hamblin, Mario Castro, Paul S. Schmidt, Peter J. Niedbalski   +11 more
wiley   +1 more source

Ocular facial myositis and sialadenitis presenting with new onset ulcerative colitis

JPGN Reports, EarlyView.
Abstract Extra‐intestinal manifestations of inflammatory bowel disease (IBD) can involve most organ systems, although the immunologic underpinnings are not well understood. Most patients who present with an extra‐intestinal manifestation have a single site of extra‐intestinal involvement; however, a small cohort presents with multiple different sites ...
Nicole Du, Nicole Mendez, Anil Darbari
wiley   +1 more source

Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis

Brazilian Journal of Otorhinolaryngology, 2014
Introduction: Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors.
Marco Antonio dos Anjos Corvo, Claudia Alessandra Eckley, Luis Vicente Rizzo, Luiz Roberto Sardinha, Tomas Navarro Rodriguez, Ivo Bussoloti Filho   +5 more
doaj   +1 more source

A Refractory Leg Skin Ulcer Associated With Multiple Myeloma Successfully Treated With Plasma Exchange, Lenalidomide, and Dexamethasone

JEADV Clinical Practice, EarlyView.
ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder that primarily presents with CRAB symptoms (calcium elevation, renal failure, anemia, and bone abnormalities). In rare cases, MM manifests with systemic complications like skin ulcers, which present management challenges. Here, we report a 78‐year‐old Japanese man with MM and refractory
Naoko Hattori, Yutaka Kuwatsuka, Tomoka Waseda, Daisuke Ehara, Koji Ando, Hiroyuki Murota   +5 more
wiley   +1 more source

Labial salivary gland biopsy: a crucial method for confirming seronegative Sjogren’s syndrome—a case report

Bulletin of the National Research Centre
Background Sjogren’s syndrome is an autoimmune disease that affects exocrine glands like sweat glands, salivary glands, and lacrimal glands. Dentists frequently encounter these patients and have an important role in establishing the diagnosis.
Satyasai S. G. Romala, Kishore Moturi, Ravikanth Manyam, Meghana Vadupu, P. Divya Naga Lakshmi, Anil Budumuru, U. Shivajiraju, J. S. D. N. Sai Hyma, R. V. S. N. S. Ramachandrudu   +8 more
doaj   +1 more source

Primary Sjögren’s syndrome with polymyositis, a rare amalgamation

Egyptian Rheumatology and Rehabilitation, 2018
Sjögren’s syndrome is characterized by diminished lacrimal and salivary gland secretory function. This disorder is not strictly confined to the exocrine glands and its manifestations may extend to extraglandular sites, such as the lungs, kidneys ...
Harpreet Singh, Deepak Jain, B Kiran, Neeraj Kumar   +3 more
doaj   +1 more source