Results 101 to 110 of about 18,250 (265)

Marcadores inmunológicos como factores pronósticos en el síndrome de Sjögren primario [PDF]

, 2006
[spa] ANTECEDENTES DEL TEMA. El síndrome de Sjögren primario (SSp) es una enfermedad autoinmune sistémica que afecta a las glándulas exocrinas, principalmente las salivales y las lacrimales, originando síntomas de sequedad.
Brito Zerón, María del Pilar
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Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Discoid Lupus Erythematosus in Genital Skin: A Case Report and Review of the Literature

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Discoid lupus erythematosus (DLE) represents the most common variant of chronic cutaneous lupus erythematosus, a skin‐specific autoimmune disorder within the broader lupus erythematosus spectrum Clinically, DLE is characterized by erythematous, scaly plaques with areas of hyperpigmentation.
Ala' Abu‐Dayeh, Daniel Miller, Alessio Giubellino   +2 more
wiley   +1 more source

Eligibility for clinical trials in primary Sjogren\u27s syndrome: lessons from the UK Primary Sjogren\u27s Syndrome Registry

Objective: To identify numbers of participants in the UK Primary Sjogren\u27s Syndrome Registry (UKPSSR) who would fulfil eligibility criteria for previous/current or potential clinical trials in primary SS (pSS) in order to optimize recruitment.Methods:
Emery P, Lanyon P, Ng WF, Jones A, James K, Sutcliffe N, Bowman SJ, Gendi N, Akil M, Dasgupta B, Barone F, Rauz S, UK Primary Sjogren's Syndrome, Gupta M, Hunter J, Fisher B, Oni C, Moots R, McLaren J, Mitchell S, Giles I, Hindmarsh V, Young-Min S, Pease CT, Saravanan V, Griffiths B, Bombardieri M, Richards A, McHugh N, Pitzalis C, Prices E, Cooper A, Isenberg D, Regan M, Coady D   +34 more
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Marinesco-Sjogren syndrome due to SIL1 mutations with a comment on the clinical phenotype

, 2013
Item does not contain fulltextBACKGROUND: Marinesco-Sjogren syndrome is an autosomal recessive cerebellar ataxia, characterised by cerebellar ataxia, myopathy, cataracts and intellectual disability, due to mutations in the SIL1 gene.
Warrenburg, B.P.C. van de, Willemsen, M.A.A.P., Lehesjoki, A.E., Horvers, M., Morava, E., Wortmann, S.B., Vermeer, S., Willemsen, M.A., Anttonen, A.K., Morava, Eva, Wortmann, S., van de Warrenburg, B.P.   +11 more
core   +1 more source

Prurigo Pigmentosa – an increasingly diagnosed dermatological condition associated with ketogenic diet

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu, Milan Vidakovic, Marcel Krauß, Julia Hyun, Frank Oellig, Thilo Gambichler, Valentina Laura Müller, Alexander Kreuter   +7 more
wiley   +1 more source

Sjogren-Larsson syndrome in dizygous twin sisters

, 1980
Two dizygous twin sisters with the Sjogren-Larsson syndrome are described. There was parental consanguinity, and the condition is inherited as an autosomal recessive. The main features are mental retardation, spastic diplegia and ichthyosis.
David, T. J.
core   +1 more source

HYPOKALEMIC PERIODIC PALSY AS THE PRIMARY PRESENTATION OF SJOGREN\u27S SYNDROME

, 2016
The most common presentations of Sjogren\u27s syndrome include dryness of eyes, oral cavity, and features of systemic scleroderma. When a patientwalks in with such classical features, it becomes easy for the clinician to diagnose and treat the patient ...
Rao, Raghavendra, Patil, Navin, Ahmed, Talha, Kadilaya, Sri Ramulu, Varghese, George, Rao N, Karthik, Venkatesh, Anusha   +6 more
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A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Examining the Role of Artificial Intelligence in Assessment: A Comparative Study of ChatGPT and Educator‐Generated Multiple‐Choice Questions in a Dental Exam

European Journal of Dental Education, EarlyView.
ABSTRACT Aim To compare the item difficulty and discriminative index of multiple‐choice questions (MCQs) generated by ChatGPT with those created by dental educators, based on the performance of dental students in a real exam setting. Materials and Methods A total of 40 MCQs—20 generated by ChatGPT 4.0 and 20 by dental educators—were developed based on ...
Nezaket Ezgi Özer, Yusuf Balcı, Gaye Bölükbaşı, Betul İlhan, Pelin Güneri   +4 more
wiley   +1 more source