Results 131 to 140 of about 28,006 (307)

Outcome parameters in studies investigating dry eye disease: A systematic literature review

open access: yesActa Ophthalmologica, EarlyView.
Abstract The development of effective therapeutics for dry eye disease (DED) is challenging due to its complex pathophysiology, heterogeneous patient presentation and the significant failure rate of previous clinical development programs. This underlines the importance of the selection of appropriate endpoints for clinical trials.
Viktoria Pai   +8 more
wiley   +1 more source

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen   +2 more
wiley   +1 more source

The impact of systemic long‐term medications for the development of age‐related macular degeneration

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Age‐related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long‐term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and ...
Hanna Heloterä   +3 more
wiley   +1 more source

Association between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study

open access: yesFrontiers in Neurology
PurposeOur study aimed to explore the correlation between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis.MethodsThis retrospective, nationwide, population-based, matched case–control investigation involved 33,190 ...
Ren-Long Jan   +10 more
doaj   +1 more source

A Non-Hodgkin’s Lymphoma Case in a Patient with Sjogren Syndrome and Covid-19 [PDF]

open access: hybrid, 2023
Nerenxa Ajasllari   +55 more
openalex   +1 more source

Chapter 6 - Cerebrospinal fluid in the dementias [PDF]

open access: yes, 2017
Alzheimer disease, vascular dementia, dementia with Lewy bodies, and frontotemporal dementia are the most common central nervous system disorders that cause progressive neurocognitive dysfunction and ultimately dementia.
Rohrer, JD, Schott, JM, Zetterberg, H
core  

IRF4 Enhances Radiosensitivity of Cervical Cancer by Inhibiting the PI3K/Akt/mTOR Pathway to Regulate Autophagy

open access: yesCancer Science, EarlyView.
IRF4 is a prognostic biomarker in cervical cancer. IRF4 enhances radiosensitivity and inhibits tumor growth via PI3K/AKT/mTOR‐mediated autophagy. IRF4 boosts radiation response in vitro and in vivo. ABSTRACT Interferon regulatory factor 4 (IRF4), a critical member of the IRF transcription factor family, harbors an elusive biological role in cervical ...
Meihui Gao   +9 more
wiley   +1 more source

Application of saliva crystalloscopy methods in the diagnosis of malignant tumours of salivary glands and Sjögren disease [PDF]

open access: yes, 2015
A high informational content of saliva crystalloscopy in the diagnosis of salivary glands tumours was proven; typical symptoms of Sjögren disease and malignant tumours of the salivary glands were found on the ground of the analysis of the presented ...
Lakhtin, Yurii Volodymyrovych   +9 more
core  

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