Results 151 to 160 of about 606,618 (284)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Comparison of cervical vertebral maturation, hand wrist skeletal maturity indicators, and dental age in growing patients: A retrospective study. [PDF]

J Orthod Sci
Kassem I, Rossouw PE, Barmak B, Michelogiannakis D, Malik S.   +4 more
europepmc   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Revision periacetabular osteotomy enhances joint function and activity level after failure of redirectional pelvic osteotomy at skeletal maturity. [PDF]

Bone Jt Open
Fischer M, Nitsch A, Goronzy J, Kasabji F, Hofer A, Wassilew GI.   +5 more
europepmc   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

Salivary hormonal analysis as a tool for skeletal maturity assessment. [PDF]

Sci Rep
Gandhi V, Gudhimella S, Bradley GT, Anibal S, Deguchi T, Yadav S, Chandiramani S, Janakiraman N.   +7 more
europepmc   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Severe Progression of Scoliosis Beyond Skeletal Maturity in Partial Trisomy 13: A Case Report Expanding the Phenotypic Spectrum. [PDF]

Cureus
Fabregas A, Lugo E, Nice E, Gupta VP, Samdani AF.   +4 more
europepmc   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source