Results 211 to 220 of about 606,618 (284)

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

open access: yesAdvanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao   +11 more
wiley   +1 more source

The impact of HIV infection on skeletal maturity in peripubertal children in Zimbabwe: a cross-sectional study. [PDF]

open access: yesBMC Pediatr
Kowo-Nyakoko F   +8 more
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li   +9 more
wiley   +1 more source

Atlas of Skeletal Maturation

open access: yesJournal of the American Medical Association, 1938
openaire   +2 more sources

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

open access: yesAdvanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou   +13 more
wiley   +1 more source

Ultrasound supports clinical decision-making in determining the Sanders' skeletal maturity score of the hand. [PDF]

open access: yesInt Orthop
Wagner F   +12 more
europepmc   +1 more source

Skeletal Maturation in Japanese

open access: yesJournal of the Anthropological Society of Nippon, 1972
openaire   +2 more sources

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