Results 131 to 140 of about 320,245 (358)
Karl Popper’s demarcation problem [PDF]
Karl Popper, as a critical rationalist, was an opponent of all forms of skepticism, conventionalism and relativism in science. A major argument of Popper is Hume's critique of induction, arguing that induction should never be used in science.
Sfetcu, Nicolae
core
The influence of professional skepticism, auditor’s experiences, and competency on fraud detection
, 2023 Retna Sari, Stefanie Andrian
openalex +2 more sources
Advanced Science, EarlyView.This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal +3 more
wiley +1 more source
Contextualism, skepticism, and invariantism
Principia: An International Journal of Epistemology, 2010 Michael Williams and Keith DeRose defend their different versions of contextualism on the grounds that contextualism gives a better account of the ordinary use of epistemic terms than invariantist competitors.
Stephen Jacobson
doaj
OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain
Advanced Science, EarlyView.OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang +10 more
wiley +1 more source
OBUSight: Clinically Aligned Generative AI for Ophthalmic Ultrasound Interpretation and Diagnosis
Advanced Science, EarlyView.OBUSight, a clinically aligned generative AI model that jointly generates reports and predicts diseases through multimodal semantic alignment, was trained and validated on a large multicenter dataset. OBUSight outperformed eight state‐of‐the‐art models, provided clinically reliable reports, enhanced diagnostic efficiency, and achieved performance ...
Xiaocong Liu +17 more
wiley +1 more source
El escepticismo en el pensamiento político e histórico de David Hume [PDF]
, 2018 This essay argues that Hume’s political and historical thought is well read as skeptical and skeptical in a way that roots it deeply in the Hellenistic traditions of both Pyrrhonian and Academical thought. It deploys skeptical instruments to undermine
Fosl, Peter S.
core
Advanced Science, EarlyView.Machine learning models predict in real time the onset of harmful microbubble collapse during microbubble‐enhanced focused ultrasound (MB‐FUS) and enable dynamic adjustment of sonication to prevent cavitation‐induced damage. This predictive control expands the safe operating window for bloodbrain barrier opening, enhancing nanoparticle delivery and ...
Hohyun Lee +17 more
wiley +1 more source