Results 61 to 70 of about 934,208 (256)

Podróż z Moskwy do Trojeckiego Klasztoru, z niektórymi historycznymi pamiątkami Nikołaja Karamzina w strukturze czasopisma „Wiestnik Jewropy” oraz całokształcie spuścizny pisarza

open access: yesPolilog: Studia Neofilologiczne, 2018
Memoires and historical commentaries on the way to The Trinity Lavra of St. Sergius by Nikolay Karamzin in the structure of the periodical “Vestnik Evropy” and Karamzin’s literary output Memoires and historical commentaries on the way to The Trinity ...
Magdalena Dąbrowska
doaj   +1 more source

Cross-domain 3D Model Retrieval Based on Viewpoint Alignment

open access: yesJournal of Harbin University of Science and Technology, 2023
3D model retrieval with sketches as input is convenient for users to express their retrieval needs, and has become a research hotspot. However, a sketch which is only the rough description of a 3D model from a single viewpoint has high degree of ...
ZHANG Libao   +4 more
doaj   +1 more source

Semantics of a Typed Algebraic Lambda-Calculus

open access: yes, 2010
Algebraic lambda-calculi have been studied in various ways, but their semantics remain mostly untouched. In this paper we propose a semantic analysis of a general simply-typed lambda-calculus endowed with a structure of vector space.
Andrzej Filinski   +20 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Documenting the Elusive and Ephemeral in Embodied Design Ideation Activities

open access: yesMultimodal Technologies and Interaction, 2018
Documenting embodied ideation activities is challenging, as they often result in ephemeral design constructs and elusive design knowledge difficult to document and represent.
Laia Turmo Vidal, Elena Márquez Segura
doaj   +1 more source

A Grammar Sketch of Kwaraqae [PDF]

open access: yes, 2010
A Grammar Sketch of Kwaraqae is a synchronic linguistic analysis of the Kwaraqae language, one of sixty-three languages which are part of the North Malaita dialect chain in the Solomon Islands.
Macdonald, Daryl Eveline
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Intervención en el edificio Clave: Valparaíso, Chile

open access: yesARQ, 2010
Como resultado de un proyecto de título que estudia el plan de Valparaíso -con sus diferentes modos de ocupación de las manzanas-, se presenta la posibilidad de intervenir un edificio de viviendas en la base del cerro Cordillera, a partir de la ...
Daniel Ruddoff
doaj  

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