Results 61 to 70 of about 934,208 (256)
Memoires and historical commentaries on the way to The Trinity Lavra of St. Sergius by Nikolay Karamzin in the structure of the periodical “Vestnik Evropy” and Karamzin’s literary output Memoires and historical commentaries on the way to The Trinity ...
Magdalena Dąbrowska
doaj +1 more source
Cross-domain 3D Model Retrieval Based on Viewpoint Alignment
3D model retrieval with sketches as input is convenient for users to express their retrieval needs, and has become a research hotspot. However, a sketch which is only the rough description of a 3D model from a single viewpoint has high degree of ...
ZHANG Libao +4 more
doaj +1 more source
Semantics of a Typed Algebraic Lambda-Calculus
Algebraic lambda-calculi have been studied in various ways, but their semantics remain mostly untouched. In this paper we propose a semantic analysis of a general simply-typed lambda-calculus endowed with a structure of vector space.
Andrzej Filinski +20 more
core +2 more sources
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Documenting the Elusive and Ephemeral in Embodied Design Ideation Activities
Documenting embodied ideation activities is challenging, as they often result in ephemeral design constructs and elusive design knowledge difficult to document and represent.
Laia Turmo Vidal, Elena Márquez Segura
doaj +1 more source
A Grammar Sketch of Kwaraqae [PDF]
A Grammar Sketch of Kwaraqae is a synchronic linguistic analysis of the Kwaraqae language, one of sixty-three languages which are part of the North Malaita dialect chain in the Solomon Islands.
Macdonald, Daryl Eveline
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Intervención en el edificio Clave: Valparaíso, Chile
Como resultado de un proyecto de título que estudia el plan de Valparaíso -con sus diferentes modos de ocupación de las manzanas-, se presenta la posibilidad de intervenir un edificio de viviendas en la base del cerro Cordillera, a partir de la ...
Daniel Ruddoff
doaj

