Results 91 to 100 of about 208,882 (239)
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
The power mapping tool: A method for the empirical research of power relations [PDF]
"This paper presents an innovative participatory method to visualize, discuss and analyze the power of different actors in a given governance field.
Schiffer, Eva
core
Invariant spatial information in sketch maps — a study of survey sketch maps of urban areas
Journal of Spatial Information Science, 2015 It is commonly recognized that free-hand sketch maps are influenced by cognitive impacts and therefore sketch maps are incomplete, distorted, and schematized. This makes it difficult to achieve a one-to-one alignment between a sketch map and its corresponding geo-referenced metric map.
Wang, Jia +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
PROGRESSIVISM AND WAR. FEMINIST DISCOURSES ON THE ARMED CONFLICT IN UKRAINE
International Journal of Social and Educational Innovation, 2023 What we propose in this article is a mapping of the main themes of feminist discourse on the conflict in Ukraine. In the first part of the paper, we will attempt an outline of the main positions on the conflict and its causes.
Maria CERNAT
doaj
Deliberations on the Life Sciences: Pitfalls, Challenges and Solutions
Journal of Deliberative Democracy, 2011 In this article I sketch several versions of the deliberative approach and then discuss five problems which confront a deliberative ethicist of contemporary problems of the life sciences, in particular about food, nature and agriculture.
Michiel Korthals
doaj +2 more sources
Mapping the Design Criterion Framework for Museum Exhibition Design Project [PDF]
, 2009 Currently, museums are struggling to develop and present their expertise by focusing on the interactive relationship with museum visitors. In order to meet the needs of museum exhibitions, an efficient and workable design process is of primary importance
Lin, Chunghung
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source