Results 81 to 90 of about 718,196 (292)

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Nonlinear free vibrations of functionally graded graphene origami-enabled auxetic metamaterial skew-microplates with variable thickness using isogeometric analysis

Defence Technology
The remarkable mechanical and physical characteristics of functionally graded (FG) graphene origami (GOri)-enabled auxetic metamaterial (GOEAM) structures, including their high strength-to-weight ratio, tunable stiffness and strength, and negative ...
Vu Ngoc Anh, Tran Van Ke, Nguyen Thi Thu Huong, Nguyen Thi Hue, Pham Hoang Tu   +4 more
doaj   +1 more source

Plate dynamics, mantle structure and tectonic evolution of the Caribbean region [PDF]

, 2013
The northeastern Caribbean exhibits high deformation and is fragmented by several faults into smaller tectonic blocks. One of these faults was the site of the catastrophic 12th of January 2010 earthquake. In this thesis I aim to constrain the main forces
How plate tearing and slabs drive reorganization of the N Caribbean plate boundary, Tectonophysics, van Benthem, S.A.C.   +2 more
core  

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

3D Printed Waveguide Slot Array Antennas

IEEE Access, 2016
Waveguide slot array antennas can have high gain, since the power distribution network (waveguide) has low loss, enabling a large aperture size. Rapid response to requirements for frequency, gain, and skew angle inspired a search for an alternative to ...
Gregory Peter Le Sage
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Static Convergence Behaviour of Discrete Kirchhoff-Mindlin Triangular Element on Rectangular Functionally Graded Material Plates [PDF]

E3S Web of Conferences
Rapid infrastructure development is consistent with the increase in innovation in structural elements. One of the main parameters in infrastructure development is materials.
Putrilan Syamnah Harahap Muthiah, Jauhari Maknun Imam, Atika Putri Cut   +2 more
doaj   +1 more source

Influence of continuity and aspect-ratio on the buckling of skew plates and plate assemblies

, 1996
New buckling interaction results are presented for skew plates and prismatic assemblies of plates, which illustrate the influence of continuity over supports for a range of aspect-ratio and loading combinations. The work follows from initial comparisons (
York, C.B., C.B. York
core   +1 more source