Results 41 to 50 of about 44,631 (264)

Skewed Compressed Caches [PDF]

2014 47th Annual IEEE/ACM International Symposium on Microarchitecture, 2014
Cache compression seeks the benefits of a larger cache with the area and power of a smaller cache. Ideally, a compressed cache increases effective capacity by tightly compacting compressed blocks, has low tag and metadata overheads, and allows fast lookups. Previous compressed cache designs, however, fail to achieve all these goals.
Sardashti, Somayeh, Seznec, André, Wood, David A.   +2 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The effect of acclimation to constant temperatures, pollution of food by heavy metals and short-term fasting on the metabolic activity of Glomeris balcanica (Diplopoda: Glomeridae) [PDF]

Web Ecology, 2000
Changing temperature regime has an important effect on the respiratory metabolism of Glomeris balcanica. A left skewing response of animals to increasing temperature is revealed and modeled. Acclimation from fluctuating to constant temperatures depresses
M. D. Argyropoulou, E. M. Papatheodorou, M. A. Tsiafouli, G. Karris, G. P. Stamou   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Techniques for Reduction of the Cogging Torque in Claw Pole Machines with SMC Cores

Energies, 2017
As one of the main parasitic parameters in permanent magnet (PM) synchronous machines (PMSMs), cogging torque is the main component of the torque ripple, which has always been the handicap in the high-performance, low-speed drive systems.
Chengcheng Liu, Jiawei Lu, Youhua Wang, Gang Lei, Jianguo Zhu, Youguang Guo   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Skew Randić Matrix and Skew Randić Energy

Transactions on Combinatorics, 2014
Let $G$ be a simple graph with an orientation $σ$, which assigns to each edge a direction so that $G^σ$ becomes a directed graph. $G$ is said to be the underlying graph of the directed graph $G^σ$. In this paper, we define a weighted skew adjacency matrix with Randć weight, the skew Randić matrix ${\bf R_S}(G^σ)$, of $G^σ$ as the real skew symmetric ...
Gu, Ran, Huang, Fei, Li, Xueliang
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave’s disease and control

BMC Molecular and Cell Biology
Background The reactivation and loss of mosaicism hypothesis due to X chromosome inactivation (XCI) skewing and escape could influence gender differences in autoimmune diseases. XCI selectively inactivates one of the two X chromosomes in females. Methods
In-Cheol Baek, Soo Yeun Sim, Byung-Kyu Suh, Tai-Gyu Kim, Won Kyoung Cho   +4 more
doaj   +1 more source