Results 101 to 110 of about 586,117 (247)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Impact of Theoretical Comprehension on Periodontal Instrumentation Skills Development. [PDF]

J Dent Educ
Oh SL, Jones D, Syme S, Mishler O, Saito H.   +4 more
europepmc   +1 more source

Exploring the Impact of Computational Thinking Interventions on Cognitive and Social Skills Development of SEND Learners: A Semi Systematic Review Protocol

Toheeb Omobolaji Lasisi
openalex   +1 more source

Development of Santriwati Skills in Arabic through the Darul Lughoh Program at Islamic Boarding Schools in Lamongan Regency

, 2022
Reni Prasetyawati, Khizanatul Hikmah
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Early Childhood Education and Care Enhances Cognitive Performance in Later Adolescence Through Non-Cognitive Skills Development and Reduced Truancy. [PDF]

J Intell
Liu J, Aziku M, Tahri D.
europepmc   +1 more source

Perceptions of the motivational climate, basic psychological needs, and life skills development in Chinese physical education students. [PDF]

Front Psychol, 2023
Zheng S, Ji X, Cheng L, Xu J, Cronin LD.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Evaluating the impact of a journal club activity on pharmacy students' learning outcomes and professional skills development. [PDF]

BMC Med Educ
Almuzaini OK, Wali SM, Harbi MH, Azhari HF.   +3 more
europepmc   +1 more source

Impact of student-run clinic participation on empathy and interprofessional skills development in medical and pharmacy students. [PDF]

Explor Res Clin Soc Pharm, 2023
Kodweis KR, Allen RB, Deschamp EI, Bihl AT, LeVine DAM, Hall EA.   +5 more
europepmc   +1 more source