Results 51 to 60 of about 90,844 (256)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Effect of Asparagus falcatus and Taraxacum javanicum Inulins on growth of L. acidophilus La-5 and B. animalis subsp lactis Bb-12, co-cultured in skim milk

Tropical Agricultural Research, 2016
A study was conducted to evaluate the effect of inulin from Asparagus falcatus and Taraxacum javanicum on growth of Lactobacillus acidophilus (La-5) and Bifidobacterium animalis (Bb-12) in skim milk.
D. C. Mudannayake, K. M. S. Wimalasiri, K. F. S. T. Silva, S. Ajlouni   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Storage evaluation of a functional food with skimmed milk enriched with fatty acids of Sacha Inchi (Plukenetia volubilis L.)

Agroindustrial Science, 2018
The aim of this study was obtain a semi skim milk enriched with sacha inchi oil (Plukenetia volubilis L.), with sensory acceptability and a suitable storage container. The raw materials used were: fresh semi skim milk of creole cow and virgin sacha inchi
Patrick García, Aníbal Quinteros, Patricia García, Julio Chumacero, Publio Castro   +4 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

PENGARUH SUPLEMENTASI FILTRAT KECAMBAH KACANG HIJAU (Phaseolus radiatus L.) TERHADAP KUALITAS SEMEN SAPI SIMMENTAL DALAM PENGENCER SKIM MILK PADA SUHU DINGIN

Jurnal Ternak Tropika, 2016
Penelitian ini bertujuan untuk mengetahui pengaruh suplementasi filtrat kecambah kacang hijau dalam pengencer skim milk terhadap kualitas semen sapi Simmental pada suhu dingin.
Ayu Melia Sades, Nurul Isnaini, Sri Wahjuningsih   +2 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Effects of different types of milk consumption on type 2 diabetes and the mediating effect of AA: A Mendelian randomization study of East Asian populations

Journal of Dairy Science
: There is currently a lack of research examining the association between the consumption of different dairy products and type 2 diabetes (T2D) in East Asian populations.
Qing-Ao Xiao, Lin Chen, Xiao-Long Li, Qiang Han, Hai-Tao Li, Xiao-Ling Zhang   +5 more
doaj   +1 more source

The Effect of Skim Milk Concentration on Sensory Quality and pH of Probiotic Yoghurt Added with Red Dragon Fruit (Hylocereus polyrhizus)

Jurnal Ilmu dan Teknologi Hasil Ternak, 2020
Probiotic yoghurt is one of dairy products that has benefits to the human health. This research aimed to understand the effect of skim milk concentration on the sensory quality traits and pH of probiotic yoghurt added with red dragon fruit (Hylocereus ...
Asterias Hafiizha, Indira Lanti Kayaputri, Tensiska Tensiska, Nur Risma Amalia   +3 more
doaj   +1 more source