Results 41 to 50 of about 452,625 (299)

Novel hydrogels based on polysaccharides for soft tissue regeneration: preparation and characterization [PDF]

, 2015
Předložená diplomová práce se zabývá přípravou, síťováním a fyzikálně-chemickou charakterizací hydrogelů na bázi polysacharidů. Cílem práce bylo vyvinout elastické filmy, které by mohly být použity pro vlhké hojení ran.
Nedomová, Eva
core  

Self-organizing & stochastic behaviors during the regeneration of hair stem cells [PDF]

, 2011
Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative ...
Andl, T, Baker, RE, Chen, CC, Chuong, CM, de la Cruz, D, Fare, C, Maini, Philip, Millar, SE, Plikus, MV, Widelitz, R   +9 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Dermatoscopy for the rapid diagnosis of Talaromyces marneffei infection: a case report

BMC Infectious Diseases, 2019
Background Talaromyces marneffei is a thermally dimorphic fungus endemic in south-east Asia. It predominantly occurs in both immunocompromised and immunosuppressed patients and can be fatal if diagnosis and treatment are delayed.
Jiayi Xian, Xiaowen Huang, Qiaofei Li, Xiaoming Peng, Xuebiao Peng   +4 more
doaj   +1 more source

Microbiome function predicts amphibian chytridiomycosis disease dynamics

Microbiome, 2022
Background The fungal pathogen Batrachochytrium dendrobatidis (Bd) threatens amphibian biodiversity and ecosystem stability worldwide. Amphibian skin microbial community structure has been linked to the clinical outcome of Bd infections, yet its overall ...
Kieran A. Bates, Ulf Sommer, Kevin P. Hopkins, Jennifer M. G. Shelton, Claudia Wierzbicki, Christopher Sergeant, Benjamin Tapley, Christopher J. Michaels, Dirk S. Schmeller, Adeline Loyau, Jaime Bosch, Mark R. Viant, Xavier A. Harrison, Trenton W. J. Garner, Matthew C. Fisher   +14 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Multicentre, Prospective, and Retrospective Registry to Characterize the Use, Effectiveness, and Safety of Dalbavancin in German Clinical Practice

Antibiotics, 2022
The antibiotic dalbavancin is approved for intravenous treatment of adults with acute bacterial skin and skin structure infections. This study aimed to observe the use, effectiveness, and safety of dalbavancin in clinical practice in Germany.
Frank Hanses, Sebastian Dolff, Janina Trauth, Michael Seimetz, Stefan Hagel   +4 more
doaj   +1 more source

Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]

, 2002
Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source