Results 41 to 50 of about 4,312,958 (304)

Secukinumab treatment in a pediatric patient with corticosteroid-intolerant pyoderma gangrenosum: a case report

Frontiers in Medicine
Pyoderma gangrenosum (PG) is a rare, rapidly progressive, non-infectious neutrophilic dermatosis characterized by severely painful ulcers. Its pathogenesis may be attributed to genetic factors, autoimmune dysfunction, and neutrophil disorders ...
Wang Liwei, Qian Yihong, Tan Fei, Yuan Chao   +3 more
doaj   +1 more source

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

Adipose Tissue–Derived Exosomes as a Novel Therapeutic Approach for Refractory Alopecia Areata: A Report of Two Cases

Case Reports in Dermatological Medicine
Alopecia areata (AA) is an autoimmune condition with unpredictable progression, negatively impacting the quality of life. Despite various therapeutic options, refractory cases remain challenging to treat. Emerging evidence highlights the regenerative and
Mohammad Ali Nilforoushzadeh, Nazila Heidari, Amirhossein Heidari, Niloufar Najar Nobari   +3 more
doaj   +1 more source

The Wonderfully Made Design of the Skin and Its Microbiome [PDF]

, 2014
Many microbes live in a mutualistic relationship with the human body, make up the human microbiome, and play a role in our health by modulating the immune system.
Gillen, Alan L.
core   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

No increased incidence of bacterial sexually transmitted infections with PrEP use among men who have sex with men in a clinic cohort

Annals, Academy of Medicine, Singapore
Pre-exposure prophylaxis (PrEP) is a highly effective biomedical intervention to prevent human immunodeficiency virus (HIV) acquisition in at-risk populations, particularly in men who have sex with men (MSM).1 However, concerns about risk compensation ...
Benson Koon Wee Yeo, Faith Tan, Linus Cheng   +2 more
doaj   +1 more source

An in vivo comparative study on ageing skin: bio-mimetic versus traditional approach to skin moisturisation [PDF]

, 2014
Skin dryness is a common condition in elderly individuals. The two main mechanisms to cosmetically alleviate this state rely on the effects of humectants and occlusive substances, mostly in combination.
Grant-Ross, Peter, Kurimo, Ritva, Tamburic, Slobodanka, Todorova, Petya   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Prevalence and associated factors of skin cancer in aged nursing home residents: A multicenter prevalence study [PDF]

, 2019
Non-melanoma-skin cancer is an emerging clinical problem in the elderly, fair skinned population which predominantly affects patients aged older than 70 years.
Akdeniz, Merve, Blume-Peytavi, Ulrike, Hahnel, Elisabeth, Kottner, Jan, Ulrich, Claas   +4 more
core   +1 more source