Results 41 to 50 of about 2,786,833 (290)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fruit, vegetable and dietary carotenoid intakes explain variation in skin-color in young caucasian women : a cross-sectional study [PDF]

, 2015
This work was supported by a scholarship top-up grant from HMRI. Kristine Pezdirc is supported by an Australian Postgraduate Awards scholarship. Melinda Hutchesson is supported by a Postdoctoral Fellowship (100177) from the National Heart Foundation of ...
Hutchesson, Melinda J., Hutchesson, Melinda J, Perrett, David, Whitehead, Ross, Clare Collins, Gozde Ozakinci, Ross Whitehead, Collins, Clare E., David Perrett, Melinda Hutchesson, Pezdirc, Kristine, Kristine Pezdirc, Collins, Clare E, Ozakinci, Gozde   +13 more
core   +1 more source

Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris

Nature Communications
Pityriasis rubra pilaris (PRP) is an inflammatory papulosquamous dermatosis, characterized by hyperkeratotic follicular papules and erythematous desquamative plaques. The precise pathogenic mechanism underlying PRP remains incompletely understood. Herein,
Peidian Shi, Wenjie Chen, Xinxing Lyu, Zhenzhen Wang, Wenchao Li, Fengming Jia, Chunzhi Zheng, Tingting Liu, Chuan Wang, Yuan Zhang, Zihao Mi, Yonghu Sun, Xuechao Chen, Shengli Chen, Guizhi Zhou, Yongxia Liu, Yingjie Lin, Fuxiang Bai, Qing Sun, Monday O. Ogese, Qiang Yu, Jianjun Liu, Hong Liu, Furen Zhang   +23 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Computer simulation of the skin reflectance spectra [PDF]

, 2003
The reflectance spectra of the human skin in visible and near-infrared (NIR) spectral region have been calculated using the Monte Carlo technique, and the specular and internal reflection on the medium surface is taken into account.
Meglinski, I. V., Matcher, S. J.
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A new method for extracting skin microbes allows metagenomic analysis of whole-deep skin [PDF]

, 2013
In the last decade, an extensive effort has been made to characterize the human microbiota, due to its clinical and economic interests. However, a metagenomic approach to the skin microbiota is hampered by the high proportion of host DNA that is ...
Francesc Calafell, Koldo Garcia-Etxebarria, Garcia-Etxebarria, Koldo, Marc Garcia-Garcerà (3214074), Mireia Coscollà (149823), Calafell, Francesc, Amparo Latorre (88013), Calafell, Francesca, Garcia-Garcerà, Marc, Koldo Garcia-Etxebarria (461325), Coscollà, Mireia, Marc Garcia-Garcerà, Amparo Latorre, Francesc Calafell (148375), Latorre, Amparo, Mireia Coscollà   +15 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Single-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease

Nature Communications
Bullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet a comprehensive understanding of the immune landscape, particularly immune-stromal crosstalk in BP, remains elusive.
Tingting Liu, Zhenzhen Wang, Xiaotong Xue, Zhe Wang, Yuan Zhang, Zihao Mi, Qing Zhao, Lele Sun, Chuan Wang, Peidian Shi, Gongqi Yu, Meng Wang, Yonghu Sun, Fuzhong Xue, Hong Liu, Furen Zhang   +15 more
doaj   +1 more source