Results 41 to 50 of about 1,899,953 (267)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A rare case of acral persistent papular mucinosis

Clinical Case Reports, 2020
In patients with asymptomatic papules of hands and feet, a clinical differential of acral persistent papular mucinosis should be thought of.
Joseph Jia‐Hong Toh, Nicholas Seng-Geok Goh, Ding Yuan Wang   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Single-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease

Nature Communications
Bullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet a comprehensive understanding of the immune landscape, particularly immune-stromal crosstalk in BP, remains elusive.
Tingting Liu, Zhenzhen Wang, Xiaotong Xue, Zhe Wang, Yuan Zhang, Zihao Mi, Qing Zhao, Lele Sun, Chuan Wang, Peidian Shi, Gongqi Yu, Meng Wang, Yonghu Sun, Fuzhong Xue, Hong Liu, Furen Zhang   +15 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Multi-organ single-cell analysis reveals PLD4 as a biomarker and potential therapeutic target of blastic plasmacytoid dendritic cell neoplasm

Cancer Cell International
Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy originating from precursors of plasmacytoid dendritic cells.
Meng Wang, Xiaotong Xue, Zhenzhen Wang, Chuan Wang, Gongqi Yu, Zihao Mi, Xu Sang, Jianwen Wang, Yongxia Liu, Xuechao Chen, Shengli Chen, Guizhi Zhou, Hong Liu, Hao Chen, Yonghu Sun, Furen Zhang   +15 more
doaj   +1 more source

Skin Lipids and Their Influence on Skin Microbiome and Skin Care

ACS Omega
Skin lipids are essential components that play crucial roles in maintaining the skin barrier, preventing transepidermal water loss, and protecting against external agents. The specific composition of lipids may vary according to factors, such as age, diet, and environmental conditions.
Raquel Allen Garcia Barbeto Siqueira, Iveta Hradkova, Vânia Rodrigues Leite-Silva, Newton Andréo-Filho, Patricia Santos Lopes   +4 more
openaire   +5 more sources

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, Volume 20, Issue 6, Page 1388-1391, June 2026.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects

Brain Stimulation, 2020
Background: Recent experiments in rats have demonstrated significant effects of VNS on hippocampal excitability but were partially attributed to hypothermia, induced by the applied VNS parameters.
Wouter Van Lysebettens, Kristl Vonck, Lars Emil Larsen, Latoya Stevens, Charlotte Bouckaert, Charlotte Germonpré, Mathieu Sprengers, Evelien Carrette, Jean Delbeke, Wytse Jan Wadman, Paul Boon, Robrecht Raedt   +11 more
doaj   +1 more source