Results 1 to 10 of about 1,627,653 (237)
Nature Communications, 2022 Microbiome composition is influenced by genetics, although the specific host genetic factors responsible are not well known. Here, the authors performed a genome-wide meta-analysis to discover host genetic effects on skin microbiota and finding potential
Lucas Moitinho-Silva +17 more
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Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases
Frontiers in Immunology, 2019 Tyrosine kinases relay signals from diverse leukocyte antigen receptors, innate immune receptors, and cytokine receptors, and therefore mediate the recruitment and activation of various leukocyte populations. Non-receptor tyrosine kinases of the Jak, Src,
Kata P. Szilveszter +2 more
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Pan-Genome and Comparative Genome Analyses of
mBio, 2013 Propionibacterium acnes constitutes a major part of the skin microbiome and contributes to human health. However, it has also been implicated as a pathogenic factor in several diseases, including acne, one of the most common skin diseases. Its pathogenic
Shuta Tomida +6 more
doaj +3 more sources
Genetic skin diseases related to desmosomes and corneodesmosomes
Journal of Dermatological Science, 2014 The integrity of the epidermis depends on the cohesion between keratinocytes, and desmosomes are the main adhesion structures. When cells become cornified, desmosomes are modified and transformed into corneodesmosomes. Mutations in the genes encoding desmosomal components underlie several skin diseases including palmoplantar keratoderma and forms of ...
Ishida-Yamamoto, Akemi, Igawa, Satomi
openaire +4 more sources
Analogs of human genetic skin disease in domesticated animals
International Journal of Women's Dermatology, 2017 Genetic skin diseases encompass a vast, complex, and ever expanding field. Recognition of the features of these diseases is important to ascertain a correct diagnosis, initiate treatment, consider genetic counseling, and refer patients to specialists ...
Justin Finch, MD +2 more
doaj +3 more sources
Ferroptosis: Mechanism and connections with cutaneous diseases
Frontiers in Cell and Developmental Biology, 2023 Ferroptosis is a recognized novel form of programmed cell death pathway, featuring abnormalities in iron metabolism, SystemXc−/glutathione axis, and lipid peroxidation regulation.
Lihao Liu +4 more
doaj +2 more sources
Genetics and Omics Analysis of Autoimmune Skin Blistering Diseases
Frontiers in Immunology, 2019 Autoimmune blistering diseases (AIBDs) of the skin are characterized by autoantibodies against different intra-/extracellular structures within the epidermis and at the basement membrane zone (BMZ). Binding of the antibodies to their target antigen leads
Michael Olbrich +8 more
doaj +2 more sources
Orphanet Journal of Rare Diseases, 2023 Background Since the beginning of human genetic research, there are very few publications sharing insights of the negative impact of rare genetic skin diseases (RGSD) on patients’ experiences. This systematic review assessed the psychosocial implications
Hugo Fournier +3 more
semanticscholar +1 more source
Experimental Dermatology, 2021 Genetic skin diseases, also known as genodermatoses, are inherited disorders affecting skin and constitute a large and heterogeneous group of diseases.
V. Jayarajan +3 more
semanticscholar +1 more source
Stem Cell Research, 2023 Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare and severe genetic disease responsible for blistering of the skin and mucosa caused by a wide variety of mutations in COL7A1 encoding type VII collagen.
Camille Vincent +5 more
doaj +1 more source