Results 131 to 140 of about 1,153,145 (290)

Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin irritation : ECVAM skin irritation task force report 2

, 2002
The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force was established in 1996, to review the status of the development and validation of alternative tests for skin irritation and corrosion, and to identify ...
E. Corsini, J. Medina, C. Wiemann, P. A. Botham, A. Coquette, J. R. Heylings, G. R. Elliott, M. Balls, M. Liebsch, J. H. Fentem, J. J. M. Van de Sandt, A. P. Worth, R. Roguet, V. Zuang, R. D. Curren   +14 more
core   +1 more source

Advancing Understanding of Subjective Liveability for People With Disability

Australian Journal of Social Issues, EarlyView.
ABSTRACT Modern liveability frameworks aim to enhance health and well‐being through equity‐based measures across built, natural, social, and economic environments, yet they often overlook the perspectives of people with disability. This study explored expectations of liveable neighbourhoods among adults with diverse disability experiences in urban and ...
Maria Hobbs, Kim Jose, Ceridwen Owen, Verity Cleland   +3 more
wiley   +1 more source

A Randomized Double-blind Study to Assess the Skin Irritation and Sensitization Potential of a Once-weekly Donepezil Transdermal Delivery System in Healthy Volunteers. [PDF]

Alzheimer Dis Assoc Disord, 2023
Sabbagh MN, Mathew P, Blau A.
europepmc   +1 more source

Proretinal nanoparticles: stability, release, efficacy, and irritation

, 2016
Pimolphan Pisetpackdeekul,1 Piyapan Supmuang,2 Porntip Pan-In,3 Wijit Banlunara,4,* Benchaphorn Limcharoen,4 Chayada Kokpol,5,* Supason Wanichwecharungruang3,6,* 1Program in Technopreneurship and Innovation Management, Graduate School, 2Program in ...
Limcharoen B, Wanichwecharungruang S, Supmuang P, Pisetpackdeekul P, Pan-In P, Kokpol C, Banlunara W   +6 more
core  

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Analysis of variability in the rabbit skin irritation assay. [PDF]

Regul Toxicol Pharmacol, 2021
Rooney JP, Choksi NY, Ceger P, Daniel AB, Truax J, Allen D, Kleinstreuer N.   +6 more
europepmc   +1 more source

Engineered 3D Fibronectin‐Based Environments Modulate the Pathogenic Profile of Arthritic Synovial Fibroblasts

Advanced NanoBiomed Research, EarlyView.
Fibroblast behavior is shaped by the surrounding microenvironment, yet conventional culture systems often fail to capture disease‐relevant phenotypes. Here, platform‐dependent responses of healthy and arthritic synovial fibroblasts are examined across 2D and 3D culture systems. Distinct inflammatory and proliferative signatures emerge, highlighting how
Aneesah Khan, Piaopiao Pan, Yanling Lan, Çağlar Çi̇l, Julia Isakova, Yilin Wang, Theodora Rogkoti, Thanutchaporn Sartyoungkul, James F. C. Windmill, Jonathan William, Manuel Salmeron‐Sanchez, Margaret H. Harnett, Oana Dobre, Miguel A. Pineda   +13 more
wiley   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Arthroscopic All‐Inside Meniscal Tying for Anterior Horn Bucket‐Handle Meniscal Injuries

Arthroscopy Techniques, EarlyView.
Abstract Anterior horn meniscal tear is a relatively uncommon injury to be seen in our knee arthroscopy surgeries. It can be a part of a bucket‐handle tear or less commonly in isolation. Several repair techniques have been used to treat this injury, with the most commonly used ones being the outside‐in and inside‐out techniques, with the disadvantage ...
Ziyad El Qirem, Wael Al‐Atout, Mohamad Makahleh, Barakat Elsaqa   +3 more
wiley   +1 more source

c-Src activation as a potential marker of chemical-induced skin irritation using tissue-engineered skin equivalents. [PDF]

Exp Dermatol, 2023
Harding AL, Colley HE, Vazquez IB, Danby S, Hasan MZ, Nakanishi H, Furuno T, Murdoch C.   +7 more
europepmc   +1 more source