In Vivo Intra-Uterine Delivery of TAT-Fused Cre Recombinase and CRISPR/Cas9 Editing System in Mice Unveil Histopathology of Pten/p53-Deficient Endometrial Cancers. [PDF]
Adv Sci (Weinh), 2023 Pten and p53 are the most frequently mutated tumor suppressor genes in endometrial carcinomas. New technical approaches such as in vivo TAT‐Cre delivery, in vivo CRISPR/Cas9 editing, xenotransplantation or organoids unveiled pathological outcome of loss of Pten/p53 ablation.
Navaridas R +11 more
europepmc +2 more sources
Neuroendocrine small cell carcinoma of the cervix: A case report. [PDF]
Mol Clin Oncol, 2021 Merkel cell polyomavirus (MCPyV) has been found in patients with Merkel cell carcinoma and respiratory tract infections. Merkel cell carcinoma is a primary aggressive neuroendocrine carcinoma of the skin.
Giordano G +5 more
europepmc +3 more sources
CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions [PDF]
Acta Neuropathologica CommunicationsErythroblastic sarcoma (ES) (previously called chloroma or granulocytic sarcoma) are rare hematological neoplams characterized by the proliferation of myeloid blasts at extramedullary sites, and primarily involve the skin and soft tissue of middle-aged ...
Arnault Tauziède-Espariat +17 more
doaj +2 more sources
Widespread pain and depression are key modifiable risk factors associated with reduced social participation in older adults: A prospective cohort study in primary care. [PDF]
Medicine (Baltimore), 2016 In older adults, reduced social participation increases the risk of poor health-related quality of life, increased levels of inflammatory markers and cardiovascular disease, and increased mortality.
Wilkie R +5 more
europepmc +5 more sources
EWSR1-The Most Common Rearranged Gene in Soft Tissue Lesions, Which Also Occurs in Different Bone Lesions: An Updated Review. [PDF]
Diagnostics (Basel), 2021 EWSR1 belongs to the FET family of RNA-binding proteins including also Fused in Sarcoma (FUS), and TATA-box binding protein Associated Factor 15 (TAF15).
Flucke U +6 more
europepmc +4 more sources
Genetic and functional characterization of disease associations explains comorbidity. [PDF]
Sci Rep, 2017 Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning.
Rubio-Perez C +9 more
europepmc +15 more sources
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. [PDF]
Br J Cancer, 2018 Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be ...
Herfs M +23 more
europepmc +3 more sources
Sarin exposure, mortality and cancer incidence in UK military veterans involved in human experiments at Porton Down: 52-year follow-up. [PDF]
Occup Environ MedObjectives We investigated whether UK military personnel exposed to sarin during the ‘Service Volunteer Programme’ at Porton Down had increased rates of mortality or cancer incidence over a 52-year follow-up.
Archer G +4 more
europepmc +4 more sources
Pathogenesis, diagnosis and management of primary melanoma of the colon. [PDF]
World J Surg Oncol, 2011 Background:Melanomas within the alimentary tract are usually metastatic in origin. On the other hand, primary melanomas of the gastrointestinal tract are relatively uncommon.
Khalid U, Saleem T, Imam AM, Khan MR.
europepmc +3 more sources
Abstract Book for the 27th Congress of the European Hematology Association [PDF]
Hemasphere, 2022 HemaSphere, Volume 6, Issue S3, Page 1-4130, June 2022.
europepmc +2 more sources