Results 21 to 30 of about 156,322 (245)

Multimodal assessment of long-term memory recall and reinstatement in a combined cue and context fear conditioning and extinction paradigm in humans. [PDF]

PLoS ONE, 2013
Learning to predict danger via associative learning processes is critical for adaptive behaviour. After successful extinction, persisting fear memories often emerge as returning fear. Investigation of return of fear phenomena, e.g.
Jan Haaker, Tina B Lonsdorf, Alexandra Thanellou, Raffael Kalisch   +3 more
doaj   +1 more source

A study of neonatal dermatoses in a tertiary care center

Indian Journal of Paediatric Dermatology, 2019
Background: Neonatal dermatoses by definition encompass the spectrum of cutaneous disorders that arise during the 1st 4 weeks of life. The appreciation of normal phenomena and their differentiation from the more significant cutaneous disorders of the ...
Vishalakshi S Pandit, K Udaya
doaj   +1 more source

Nose Heat: Exploring Stress-induced Nasal Thermal Variability through Mobile Thermal Imaging

, 2019
Automatically monitoring and quantifying stress-induced thermal dynamic information in real-world settings is an extremely important but challenging problem.
Bianchi-Berthouze, Nadia, Cho, Youngjun, Holloway, Catherine, Julier, Simon, Oliveira, Manuel   +4 more
core   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

EPIC: Examining Patch Impedance Characteristics [PDF]

, 2019
In the United States, approximately one in 4 adults have at least one chronic illness, making up approximately 84% of US Healthcare Spending. Unfortunately, 50% of patients with chronic diseases do not take their medication properly and as such spend ...
Buck, Shane, Gopinath, Jyotsna, Markfield, Kyle   +2 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis

Scientific Reports
Sweat is an essential protection system for the body, but its failure can result in pathologic conditions, including several skin diseases, such as palmoplantar pustulosis (PPP).
Kazuki Yatsuzuka, Ryosuke Kawakami, Yosuke Niko, Teruko Tsuda, Kenji Kameda, Nobushige Kohri, Satoshi Yoshida, Ken Shiraishi, Jun Muto, Hideki Mori, Yasuhiro Fujisawa, Takeshi Imamura, Masamoto Murakami   +12 more
doaj   +1 more source

Microbial lysate upregulates host oxytocin [PDF]

, 2017
Neuropeptide hormone oxytocin has roles in social bonding, energy metabolism, and wound healing contributing to good physical, mental and social health. It was previously shown that feeding of a human commensal microbe Lactobacillus reuteri (L.
Alm, Eric J., Cheung, Harry K., DiBenedictis, Brett T., Didyk, Eliska, Erdman, Susan E., Hardas, Alexandros, Ibrahim, Yassin, Kolandaivelu, Kumaran, Levkovich, Tatiana, Poutahidis, Theofilos, Ricciardi, Catherine E., Shikhman, Lana, Varian, Bernard J., Veenema, Alexa H.   +13 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

A 3D-Printed Piezoelectric Microdevice for Human Energy Harvesting for Wearable Biosensors

Micromachines
The human body is a source of multiple types of energy, such as mechanical, thermal and biochemical, which can be scavenged through appropriate technological means.
Ihor Sobianin, Sotiria D. Psoma, Antonios Tourlidakis   +2 more
doaj   +1 more source