Results 91 to 100 of about 45,678 (245)

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

On the Modelling of Hyperspectral Light and Skin Interactions and the Simulation of Skin Appearance Changes Due to Tanning

, 2015
The distinctive visual attributes of human skin are largely determined by its interactions with light across different spectral domains. Accordingly, the modelling of these interactions has been the object of extensive investigations in numerous fields ...
Chen, Tenn Francis
core  

Evaluation of safety and skin tolerability of organic cotton pads in case of irritative vulvitis

, 2018
BACKGROUND: The woman vaginal environment is a fragile and delicate ecosystem that is often impaired by physical and chemical agents. This condition tends to damage skin barrier causing allergic reactions that lead to chronic irritating conditions ...
BUZZELLA, ALICE, Mori, Michela, Angelinetta, Claudio, Carones, Maurizio Barbieri, Pastoris, Ornella, Praticò, Antonella, Villa, Roberta, Vicini, Riccardo, Badiale, Silvia Busoli   +8 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Bending‐Resistant Intimate 3D Graphene–Metal Heterojunctions for Highly Sensitive and Robust Flexible Sensors

Advanced Science, EarlyView.
A reservoir‐guided silver‐nanoparticle soldering strategy is developed for bending‐resistant 3D graphene–metal heterojunctions. Controlled hot‐plate evaporation confines conductive ink within the metal reservoir, suppressing spreading and protecting the LIG interface from deformation‐induced fracture.
Saeyoung Park, Yoo‐Kyum Shin, Na‐Kyoung Yang, Gyeong‐Hwan Park, Somi Lee, Min‐Ho Seo   +5 more
wiley   +1 more source

Endocannabinoids limit excessive mast cell maturation and activation in human skin

, 2012
Background: Mast cells (MCs) crucially contribute to many inflammatory diseases. However, the physiological controls preventing excessive activities of MCs in human skin are incompletely understood.
Gibbs, Bernhard F, Gibbs, Bernhard F., Koji Sugawara, Daisuke Tsuruta, Balázs I. Tóth, Zimmer, Anne, Zimmer, Andreas, Anne Zimmer, Zákány, Nóra, Bernhard F. Gibbs, Tsuruta, Daisuke, Tóth, Balázs I., Ralf Paus, Arno Kromminga, Funk, Wolfgang, Nóra Zákány, Sugawara, Koji, Bíró, Tamás, Tamás Bíró, Paus, Ralf, Wolfgang Funk, Kromminga, Arno, Andreas Zimmer, Tóth, Balázs I   +23 more
core   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Heat stroke: opioid-mediated mechanisms

, 1996
Romanovsky, Andrej A., and Clark M. Blatteis. Heat stroke: opioid-mediated mechanisms. J. Appl. Physiol. 81(6): 2565–2570, 1996.—In our previous study in guinea pigs, intensive and prolonged intraperitoneal heating (IPH) caused heat stroke characterized
Andrej A. Romanovsky, Clark M. Blatteis
core   +1 more source