Results 141 to 150 of about 3,094,277 (239)

A decade of clinical trials in Italy (2016-2025): trends, regulatory transformation and biotechnological evolution. [PDF]

Front Pharmacol
De Paola E, Dri DA, Verrelli NM, Galliccia F.   +3 more
europepmc   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Orthometria: Metric Fixation in Digital Health and a Framework for Responsible Use in High-Performance Sport. [PDF]

Sports Med Open
Miller DJ, Lastella M, Miles AR.
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Physiology is a hidden dimension of diversity in the radiation of woodland salamanders. [PDF]

Proc Natl Acad Sci U S A
Alomar NM, Camarillo H, Burress ED, Laterza-Barbosa J, Gade MR, Domínguez-Guerrero SF, Hernández-Rodríguez I, Alencar LRV, Bodensteiner BL, Burger IJ, Riddell EA, Muñoz MM.   +11 more
europepmc   +1 more source

Multi‐Target Wireless Localization of Miniaturized Magneto–Oscillatory Trackers in Soft Biological Tissues

Advanced Science, EarlyView.
Miniaturized, frequency‐encoded magneto–oscillatory trackers enable wireless localization of multiple targets without prior knowledge of their positions or orientations. The method achieves accurate localization over clinically relevant distances and measures local viscoelasticity via the oscillatory responses.
Liyuan Tan, Jyothi Kumari Mariyanna, Meng Zhang, Alexander Kutscher, Ann‐Sophia Müller, Felix Fischer, Tian Qiu   +6 more
wiley   +1 more source

From facing fears to experimental frontiers: immersive cinematic virtual reality environments as a catalyst for innovation in behavioral neuroscience. [PDF]

Front Psychiatry
Berg S, Fletcher PC, Robbins TW, Milton AL.   +3 more
europepmc   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Destroyed Melanocytes Manifested with Poliosis and Halo Nevi in Children: Proposed Immunopathophysiological Mechanisms with Emphasis on Hair Follicle Immune Privilege. [PDF]

Clin Pract
Bulat V, Paštar Z, Speeckaert R, Marušić D, Zanze L, Lugović-Mihić L.   +5 more
europepmc   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source