Results 1 to 10 of about 11,506 (215)

Direct observation of the uptake of outer membrane proteins by the periplasmic chaperone Skp. [PDF]

PLoS ONE, 2012
The transportation of membrane proteins through the aqueous subcellular space is an important and challenging process. Its molecular mechanism and the associated structural change are poorly understood.
Zhi-Xin Lyu, Qiang Shao, Yi Qin Gao, Xin Sheng Zhao   +3 more
doaj   +2 more sources

Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors [PDF]

Nature Communications
RAF activation is essential for MAPK signaling and is mediated by RAS binding and the dephosphorylation of a conserved phosphoserine by the SHOC2–RAS–PP1C complex.
Daniel A. Bonsor, Lorenzo I. Finci, Jacob R. Potter, Lucy C. Young, Vanessa E. Wall, Ruby Goldstein de Salazar, Katie R. Geis, Tyler Stephens, Joseph Finney, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu   +11 more
doaj   +2 more sources

Effects of Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway

Frontiers in Pharmacology, 2022
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, so there is an urgent need to suppress its development at early stage. Shenkang pills (SKP) are a hospital prescription selected and optimized from effective traditional Chinese ...
Fujing Wang, Jia’er Fan, Tingting Pei, Zhuo’en He, Jiaxing Zhang, Liliang Ju, Zhongxiao Han, Mingqing Wang, Wei Xiao   +8 more
doaj   +1 more source

SKP-SC-EVs Mitigate Denervated Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation and Improving Microcirculation

Antioxidants, 2021
Denervated muscle atrophy is a common clinical disease that has no effective treatments. Our previous studies have found that oxidative stress and inflammation play an important role in the process of denervated muscle atrophy.
Wei Wang, Dingding Shen, Lilei Zhang, Yanan Ji, Lai Xu, Zehao Chen, Yuntian Shen, Leilei Gong, Qi Zhang, Mi Shen, Xiaosong Gu, Hualin Sun   +11 more
doaj   +1 more source

Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells

Stem Cell Research & Therapy, 2021
Background Patients with peripheral nerve injury (PNI) often suffer from hypoxic ischemic impairments, in particular when combined with vascular damage, causing neuronal dysfunction and death.
Meng Cong, Mi Shen, Xia Wu, Yan Li, Liting Wang, Qianru He, Haiyan Shi, Fei Ding   +7 more
doaj   +1 more source

Inflammation Alters the Secretome and Immunomodulatory Properties of Human Skin-Derived Precursor Cells

Cells, 2020
Human skin-derived precursors (SKP) represent a group of somatic stem/precursor cells that reside in dermal skin throughout life that harbor clinical potential.
Joery De Kock, Robim Marcelino Rodrigues, Steven Branson, Lieven Verhoye, Haaike Colemonts-Vroninks, Matthias Rombaut, Joost Boeckmans, Jessie Neuckermans, Sien Lequeue, Karolien Buyl, Makram Merimi, Douaa Moussa Agha, Veerle De Boe, Laurence Lagneaux, Philip Meuleman, Tamara Vanhaecke, Mehdi Najar   +16 more
doaj   +1 more source

Kepribadian Introvert Dan Ekstrovert Berbasis Pumping HR Model Terhadap Sasaran Kerja Pegawai Negeri Sipil Dinas Pertanian Kota Bogor

Jurnal Manajemen, 2020
Good governance is a set of processes that are implemented in an organization to make a decision. Human self can not be separated from the so-called personality. Personality is a dynamic organization of individual psycho-physical systems.
Didong Suherbi, , Ahmad Juwaini, Amir Tengku Ramly   +2 more
doaj   +1 more source

Intracarotid Transplantation of Skin-Derived Precursor Schwann Cells Promotes Functional Recovery After Acute Ischemic Stroke in Rats

Frontiers in Neurology, 2021
Purpose: Skin-derived Precursor Schwann cells (SKP-SCs) have been reported to provide neuroprotection for the injured and dysmyelinated nervous system. However, little is known about SKP-SCs on acute ischemic stroke (AIS).
Jingjing Liang, Jingjing Liang, Ronghui Cui, Ronghui Cui, Jinglei Wang, Jinglei Wang, Jiabing Shen, Jiabing Shen, Ying Chen, Ying Chen, Maosheng Cao, Maosheng Cao, Kaifu Ke, Kaifu Ke   +13 more
doaj   +1 more source

Miura and Darboux transformations in the SUSY KP hierarchies

Nuclear Physics B, 2022
The Miura links between the KP and modified KP hierarchies are extended to the SUSY KP (SKP) and SUSY modified KP hierarchies (SmKP) of Manin Radul and Jacobian types.
Huizhan Chen, Jipeng Cheng, Zhiwei Wu
doaj   +1 more source

Correlation of Seismicity With Faults in the South Korea Plateau in the East Sea (Japan Sea) and Seismic Hazard Assessment

Frontiers in Earth Science, 2022
The South Korea Plateau (SKP) is a structural high at the eastern continental margin of the Korean Peninsula. Earthquakes occur frequently in the SKP although they are not larger than ML 5.0 in magnitude.
Han-Joon Kim, Seonghoon Moon, Hyeong-Tae Jou, Kwang-Hee Kim, Bo Yeon Yi   +4 more
doaj   +1 more source