Results 1 to 10 of about 410,397 (168)

Distinct molecular profiles of skull bone marrow in health and neurological disorders

Cell, 2023
Summary The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear.
Claire Delbridge, Zeynep Ilgin Kolabas, Michael Sterr   +2 more
exaly   +2 more sources

SynthStrip: skull-stripping for any brain image [PDF]

NeuroImage, 2022
The removal of non-brain signal from magnetic resonance imaging (MRI) data, known as skull-stripping, is an integral component of many neuroimage analysis streams. Despite their abundance, popular classical skull-stripping methods are usually tailored to
Andrew Hoopes, Jocelyn S. Mora, Adrian V. Dalca, B. Fischl, Malte Hoffmann   +4 more
semanticscholar   +1 more source

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

Science, 2021
Getting around the blood–brain barrier The meninges comprise three membranes that surround and protect the central nervous system (CNS). Recent studies have noted the existence of myeloid cells resident there, but little is known about their ontogeny and
A. Cugurra, Tornike Mamuladze, Justin Rustenhoven, Taitea Dykstra, Giorgi Beroshvili, Zev J. Greenberg, Wendy Baker, Zachary Papadopoulos, Antoine Drieu, Susan M. Blackburn, M. Kanamori, S. Brioschi, J. Herz, Laura G. Schuettpelz, M. Colonna, I. Smirnov, J. Kipnis   +16 more
semanticscholar   +1 more source

Skull bone marrow channels as immune gateways to the central nervous system

Nature Neuroscience, 2023
Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called ‘skull channels’) connecting the meninges with the skull and vertebral bone marrow has revealed a new layer of ...
J. Mazzitelli, Fadi E Pulous, Leon C. D. Smyth, Zeynep Kaya, Justin Rustenhoven, Michael A. Moskowitz, Jonathan Kipnis, M. Nahrendorf   +7 more
semanticscholar   +1 more source

Pineal metastasis as first clinical manifestation of colorectal adenocarcinoma: case report [PDF]

Arquivos de Neuro-Psiquiatria, 1999
Cerebral metastases from colorectal adenocarcinomas occur in 8% of the cases. Diagnosis is usually made when primary disease and widespread metastases are already known.
RICARDO RAMINA, MAURÍCIO COELHO NETO, WAGNER M. MARIUSHI, WALTER O. ARRUDA   +3 more
doaj   +1 more source

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

Nature Neuroscience, 2022
It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura–skull channels, and CSF proteins signal onto diverse cell types within the ...
J. Mazzitelli, Leon C. D. Smyth, Kevin A Cross, Taitea Dykstra, Jerry Sun, Si-Ling Du, Tornike Mamuladze, I. Smirnov, Justin Rustenhoven, J. Kipnis   +9 more
semanticscholar   +1 more source

Chordomas and chondrosarcomas of the skull base: treatment and outcome analysis in a consecutive case series of 24 patients

World Journal of Surgical Oncology, 2021
Background We present our 9-year consecutive case series of skull base chordomas and chondrosarcomas from a UK tertiary referral centre, discussing treatments offered and outcomes.
Christopher Metcalfe, Jameel Muzaffar, Kevin Kulendra, Paul Sanghera, Simon Shaw, Amjad Shad, Natarajan Saravanappa, Alessandro Paluzzi, Shahzada Ahmed   +8 more
doaj   +1 more source

Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis

Nature Neuroscience, 2022
Interactions between the immune and central nervous systems strongly influence brain health. Although the blood–brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues facilitate intersystem communication.
Fadi E. Pulous, Jean C. Cruz-Hernández, Chong-Bo Yang, Zeynep Kaya, Alexandre Paccalet, G. Wojtkiewicz, Diane E. Capen, Dennis Brown, Juwell W. Wu, M. J. Schloss, Claudio Vinegoni, Dmitry Richter, Masahiro Yamazoe, Maarten Hulsmans, N. Momin, J. Grune, D. Rohde, C. McAlpine, Peter R. Panizzi, R. Weissleder, Dong-Eog Kim, F. Swirski, Charles P. Lin, M. Moskowitz, M. Nahrendorf   +24 more
semanticscholar   +1 more source

Nasoseptal Flap for Skull Base Reconstruction in a Three-Year-Old Child With Nasofrontal Meningoencephalocele

Ear, Nose & Throat Journal, 2023
Congenital anterior skull base defects with meningoencephaloceles causing nasal obstruction and cerebrospinal fluid (CSF) rhinorrhea are rare clinical entities. Traditionally, skull base defects have been repaired via a bifrontal craniotomy.
Jördis Kristin Eden MD, Arne Böttcher MD, Christian Stephan Betz MD   +2 more
doaj   +1 more source

Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis

Cell, 2021
Summary Craniosynostosis results from premature fusion of the cranial suture(s), which contain mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with brain growth.
Mengfei Yu, Li Ma, Yuan Yuan, Xin Ye, A. Montagne, Jinzhi He, T. Ho, Yingxi Wu, Zhen Zhao, N. Maria, R. Jacobs, M. Urata, Huiming Wang, B. Zlokovic, Jian-Fu Chen, Y. Chai   +15 more
semanticscholar   +1 more source