Results 191 to 200 of about 393,263 (322)

Different coding characteristics between flight and freezing in dorsal periaqueductal gray of mice during exposure to innate threats

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 491-501, December 2022., 2022
Flight and freezing are two vital defensive behaviors in the process of avoiding natural enemies in mice. We investigated the neural activity in dPAG nuclei of mice under two defensive behaviors, and found different coding features between flight and freezing behaviors. Abstract Background Flight and freezing are two vital defensive behaviors that mice
Denghui Liu, Shouhao Li, Liqing Ren, Xinyu Liu, Xiaoyuan Li, Zhenlong Wang   +5 more
wiley   +1 more source

The Metamerism of the Head and the Vertebrate Theory of the Skull [PDF]

, 1888
C. Gegenbaur
openalex   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

The role of nitric oxide in the dorsomedial periaqueductal gray (dmPAG) column in cardiovascular responses in urethane‐anesthetized male rats

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 557-564, December 2022., 2022
In the current study, after anesthetized rat with urethan the femoral artery was cannulated, then its head was mounted on a stereotaxic instrument and drugs (saline‐NAME, L‐Arg, and L_Arg+ L‐NAME) microinjected into the dmPAG and cardiovascular responses that recorded by a Power lab were evaluated.
Mohammad Najaftomaraei, Atiyeh Ghorbani, Alireza Rahimi, Reza Mohebbati, Sogol Sherkat, Mohammad Naser Shafei   +5 more
wiley   +1 more source

Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3‐Deficient Rats

Advanced Science, EarlyView.
This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier, Keerthi Thirtamara Rajamani, Shai Netser, Shlomo Wagner, Hala Harony‐Nicolas   +4 more
wiley   +1 more source

Metabolomic and Cellular Mechanisms of Drug‐Induced Ototoxicity and Nephrotoxicity: Therapeutic Implications of Uric Acid Modulation

Advanced Science, EarlyView.
Drug‐induced renal damage impairs uric acid excretion, causing its accumulation in the serum, which subsequently infiltrates the cochlea. Xanthine oxidase and the ABCG2 transporter, critical in uric acid metabolism and excretion, undergo pathological changes in renal tubular and cochlear stria vascularis cells.
Suhan Guo, Cheng Cheng, Yunhao Wu, Kaidi Shen, Depeng Zhang, Bin Chen, Xinyu Wang, Luping Shen, Qixiang Zhang, Renjie Chai, Guangji Wang, Fang Zhou   +11 more
wiley   +1 more source

ON THE STRUCTURE OF THE PLESIOSAURIAN SKULL [PDF]

, 1903
S. W. Williston
openalex   +1 more source

Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration

Advanced Science, EarlyView.
These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma, Chen Lei, Tao Ye, Qian‐Qian Wan, Kai‐Yan Wang, Yi‐Na Zhu, Ling Li, Xu‐Fang Liu, Long‐Zhang Niu, Franklin R. Tay, Zhao Mu, Kai Jiao, Li‐Na Niu   +12 more
wiley   +1 more source

Multi‐Shank 1024 Channels Active SiNAPS Probe for Large Multi‐Regional Topographical Electrophysiological Mapping of Neural Dynamics

Advanced Science, EarlyView.
This research article introduces a novel CMOS neural probe with 1024 channels distributed across eight shanks. The SiNAPS probe allows for the simultaneous recording of both local field potentials and action potentials in large brain areas. The probe's design allows for detailed mapping and linking neural dynamics and population unit activity, as ...
Gian Nicola Angotzi, Mihály Vöröslakos, Nikolas Perentos, Joao Filipe Ribeiro, Matteo Vincenzi, Fabio Boi, Aziliz Lecomte, Gabor Orban, Andreas Genewsky, Gerrit Schwesig, Deren Aykan, György Buzsáki, Anton Sirota, Luca Berdondini   +13 more
wiley   +1 more source

Computer vision-guided rapid and precise automated cranial microsurgeries in mice. [PDF]

Sci Adv
Navabi ZS, Peters R, Gulner B, Cherkkil A, Ko E, Dadashi F, Brien JO, Feldkamp M, Kodandaramaiah SB.   +8 more
europepmc   +1 more source