Results 41 to 50 of about 601,034 (337)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri [PDF]
, 2014 In vivo bone strain data are the most direct evidence of deformation and strain regimes in the vertebrate cranium during feeding and can provide important insights into skull morphology.
Evans, S. E. +5 more
core +3 more sources
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
Multi Agent Modelling: Evolution and Skull Thickness in Hominids [PDF]
, 2004 Within human evolution, the period of Homo Erectus is particularly interesting since in this period, our ancestors have carried thicker skulls than the species both before and after them. There are competing theories as to the reasons of this enlargement
Tüzer, senior student Sinan, F. +1 more
core
On Matching Skulls to Digital Face Images: A Preliminary Approach
, 2017 Forensic application of automatically matching skull with face images is an important research area linking biometrics with practical applications in forensics.
Jain, Arushi +5 more
core +1 more source
Scientific Reports, 2023 To compare the safety and effectiveness of surgical treatment of jugular paragangliomas (JPs) following the application of our modified surgical techniques.
Peng Zhao +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich +10 more
wiley +1 more source
Floristics, structure and site characteristics of "Melaleuca viridiflora" (Myrtaceae) dominated open woodlands of the wet tropics lowlands [PDF]
, 2008 Tropical lowland plant communities in north-eastern Queensland remain under pressure from continuing clearing, fragmentation, exotic species invasion, inappropriate fire regimes, and altered hydrological patterns. Comparatively little scientific research
Congdon, Robert A., Skull, Stephen D.
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini +13 more
wiley +1 more source
Head & Face MedicinePurpose Nasoseptal perforations (NSP) are a clinically heterogeneous group of disorders with a wide range of available treatments. Patient-reported outcome measures (PROMs) can provide valuable insights for assessing clinical and surgical outcomes.
Beatriz Arana-Fernández +4 more
doaj +1 more source