Results 121 to 130 of about 28,352,789 (316)

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Technical nuances for maximising the sublacerum versus supralacerum expanded endoscopic endonasal transclival approach: maximing extent of resection of chordomas, chondrosarcomas and petroclival lesions

Brain and Spine, 2022
A. Zammit, P. Gimenez, W. Ramcharan, J. Sinnott, W. Bennett, K. Abhinav   +5 more
doaj   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Skull Base Clear Cell Carcinoma, Metastasis of Renal Primary Tumor: A Case Report and Literature Review [PDF]

, 2013
Ilson Sepúlveda, Enrique Platín, Rodrigo Klaassen, Loreto Spencer, César Chian García, Ricardo Escarcega Alarcon, David Ulloa   +6 more
openalex   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Endoscopic Transcanal Approach to Lateral Skull Base Lesions

, 2018
Preetam Chappity, Dilip Samal, Anjan Kumar Sahoo, Saurav Sarkar, Pradeep Pradhan, Pradipta Parida   +5 more
openalex   +1 more source

Endoscopic ventral skull base surgery: Is early postoperative imaging warranted for detecting complications? [PDF]

, 2014
Lucía Sobrino Díaz, Leila J. Mady, Zachary Mendelson, James K. Liu, Jean Anderson Eloy   +4 more
openalex   +1 more source

Development of a Convolutional Neural Network Based Skull Segmentation in MRI Using Standard Tesselation Language Models [PDF]

, 2021
Rodrigo Dalvit Carvalho da Silva, Thomas R. Jenkyn, Victor Alexander Carranza   +2 more
openalex   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

A Systematic Review: State of the Science on Diagnostics of Hidden Hearing Loss

Diagnostics
Background/Objectives: A sizeable population of patients with normal pure-tone audiograms endorse a consistent difficulty of following conversations in noisy environments.
Sunil Shenoy, Khushi Bhatt, Yalda Yazdani, Helia Rahimian, Hamid R. Djalilian, Mehdi Abouzari   +5 more
doaj   +1 more source