Results 21 to 30 of about 44,123 (253)

From Rigid to Soft Robotic Approaches for Neuroendoscopy

Advanced Robotics Research, EarlyView.
Robotic assistance has had minimal impact on deep intraventricular surgeries, where small‐scale, precision, and reduced invasiveness can contribute to improved patient outcomes. Emerging technologies in rigid, soft, and hybrid robotics are reviewed to identify the most promising mechanisms for deep brain navigation in addition to an attempt to identify
Kieran Gilday, Irena Zubak, Andreas Raabe, Josie Hughes   +3 more
wiley   +1 more source

Combining morphological and functional imaging parameters to diagnose primary bone neoplasms in the skull base, spine and sacrum

Purpose Morphological magnetic resonance (MR) and computed tomography (CT) features are used in combination with histology for diagnosis and treatment selection of primary bone neoplasms.
Kro, l A.D.G., Bovee, J.V.M.G., Bloem, J.L., Miladinovic, V., Lam, S.W., Peul, W.C., Verbist, B.M., Navas Canete, A.   +7 more
core   +3 more sources

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Endoscopic Anterior Skull Base Resection for Esthesioneuroblastoma

, 2012
Esthesioneuroblastomas (ENB) are relatively rare neoplasms accounting for less than 5% of malignant sinus tumors. The presentation, preoperative evaluation, imaging, and staging are described.
Snyderman, Carl H, Mintz, Arlan H, Roy R. Casiano, Carrau, Ricardo L, Adam M. Zanation, Zanation, Adam M, Paul A. Gardner, Arlan H. Mintz, Mitchell, Candace A, Daniel M. Prevedello, Gardner, Paul A, Amin B. Kassam, Prevedello, Daniel M, Casiano, Roy R, Kassam, Amin B, Ricardo L. Carrau, Carl H. Snyderman, Candace A. Mitchell   +17 more
core   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Chordomas and Chondrosarcomas of the Posterior Fossa

, 2022
Skull base chordomas and chondrosarcomas are rare bone neoplasms that develop around the clivus and the petroclival region. Although they are quite similar in terms of clinical and radiological features, chordomas and chondrosarcomas differ with regard ...
Lieber, Stefan, Abbritti, Rosaria Viola, Fava, Arianna, Passeri, Thibault, di Russo, Paolo, Giammattei, Lorenzo, Froelich, Sébastien, Bernat, Anne Laure   +7 more
core  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Etiology and pathogenesis of glomus tumours (chemodectomas) of the base of the skull

, 2020
The objective of the present work was to describe the poorly known history of the development of the nomenclature of glomus tumours (chemodectomas) of the base of the skull, elucidate etiology and pathogenesis of these neoplasms.
Antoniv V.F., Antoniv T.V., Aksenov V.M., Koval' I.V., Popadyuk V.I.   +4 more
core   +2 more sources

Minimally Invasive Approaches to the Anterior Skull Base

, 2013
The use of minimally invasive approaches to the anterior skull base is a valuable tool to improving the treatment in patients with aggressive anterior skull base neoplasms. This article discusses the history, advantages and disadvantages relative to open
Jahangiri, Arman, Aghi, Manish K, El-Sayed, Ivan H, Ivan, Michael E   +3 more
core   +1 more source