Results 121 to 130 of about 7,845 (315)
DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics
Advanced Science, EarlyView.This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei +12 more
wiley +1 more source
Continuous Skyline Queries Based on MapReduce
Dianxin kexue, 2014 With the development of Web and wireless sensor networks, the appearance of big data has brought a great challenge to data query and process. The parallel Skyline computing issue of a moving query object under the MapReduce framework was studied.
Guanmin Shan, Yihong Dong, Xianmang He
doaj +2 more sources
Advanced Science, EarlyView.Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi +7 more
wiley +1 more source
An efficient constructive heuristic for the rectangular packing problem with rotations. [PDF]
PLoS One, 2023 Zhao X +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy +16 more
wiley +1 more source
A P2P multi-path routing algorithm based on Skyline operator for data aggregation in IoMT environments. [PDF]
PeerJ Comput Sci, 2023 Kertiou I +4 more
europepmc +1 more source
An Efficient Index-Based Method for Skyline Path Query over Temporal Graphs with Labels [PDF]
, 2023 Linlin Ding, Gang Zhang, Ji Ma, Mo Li
openalex +1 more source
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models
Advanced Science, EarlyView.Direct‐current produces nerve lesioning through discrete electrochemical reactions. Using hypoxia‐sensitive locust nerves and hypoxia‐tolerant leech nerves, we map three injury pathways: cathodic oxygen reduction, cathodic alkalization, and anodic chloride oxidation. These findings establish electrochemical lesioning—the “Faraday Scalpel”—as a precise,
Petra Ondráčková +5 more
wiley +1 more source