Results 41 to 50 of about 1,031 (230)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Anti-Invariant Riemannian Submersions from Cosymplectic Manifolds [PDF]

, 2013
We introduce anti-invariant Riemannian submersions from cosymplectic manifolds onto Riemannian manifolds. We survey main results of anti-invariant Riemannian submersions defined on cosymplectic manifolds. We investigate necessary and sufficient condition
Erken, I. Küpeli, Murathan, C.
core  

Riemannian submersions from almost contact metric manifolds

, 2011
In this paper we obtain the structure equation of a contact-complex Riemannian submersion and give some applications of this equation in the study of almost cosymplectic manifolds with Kaehler fibres.Comment: Abh. Math. Semin. Univ.
A. Bonome, A. Gray, A. M. Ionescu, B. O’Neill, B. Sahin, B. Watson, B. Watson, B. Watson, B. Watson, B. Watson, B.-Y. Chen, D. Chinea, D. Chinea, D.E. Blair, E. Vergara-Diaz, F. Narita, G. Băditoiu, G. E. Vîlcu, G.E. Vîlcu, G.E. Vîlcu, J. Cabrerizo, J.P. Bourguignon, M. Falcitelli, M. Falcitelli, M. Vişinescu, M.T. Mustafa, R. Escobales, R. Mocanu, R. Mocanu, S. Ianuş, S. Ianuş, S. Ianuş, S. Ianuş, S. Ianuş, S. Ianuş, S. Kobayashi, T. Tshikuna-Matamba, V. Cortés, Z. Olszak   +38 more
core   +1 more source

Slant submersions in paracontact geometry

Hacettepe Journal of Mathematics and Statistics, 2020
In this paper, we investigate some geometric properties of three types of slant submersions whose total space is an almost paracontact metric manifold.
openaire   +5 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Slant submersions from almost paracontact Riemannian manifolds

Kuwait Journal of Science, 2015
In this paper, we introduce slant submersions from almost paracontact Riemannian manifoldsonto Riemannian manifolds. We give examples and investigate the geometry of foliationswhich are arisen from the definition of a Riemannian submersion.
YILMAZ GÜNDÜZALP
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Geodesics on an invariant surface [PDF]

, 2009
We study the geodesics on an invariant surface of a three dimensional Riemannian manifold. The main results are: the characterization of geodesic orbits; a Clairaut's relation and its geometric interpretation in some remarkable three dimensional spaces ...
I. Onnis, Irene, Stefano Montaldo
core