Results 71 to 80 of about 492,369 (276)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A Bottom‐Up Design Framework for Multifunctional Lattice Metamaterials

Advanced Science, EarlyView.
This study introduces a generative AI framework for designing multifunctional lattice metamaterials. The method combines 3D Gaussian voxel generation with deep learning, enabling greater design freedom and structural performance. The optimized lattice metamaterials achieve enhanced energy absorption by 40–200% compared to conventional structures and ...
Zongxin Hu, Quanqing Tao, Junhao Ding, Shuo Qu, Haitao Ye, Jun Wei Chua, Tianxiao Niu, Rui Li, Winston Wai Shing Ma, Haoming Mo, Hui Liu, Wei Zhai, Xinwei Li, Xu Song   +13 more
wiley   +1 more source

Atomic Model of Susy Hubbard Operators

, 2002
We apply the recently proposed susy Hubbard operators to an atomic model. In the limiting case of free spins, we derive exact results for the entropy which are compared with a mean field + gaussian corrections description.
A. Auerbach, A. Auerbach, A. Schroeder, A.A. Abrikosov, A.J. Millis, A.J. Millis, C. Jayaprakash, C. Panagopoulos, C. Pépin, C. Pépin, C.L. Kane, C.M. Varma, D. Yoshioka, D. Yoshioka, D.P. Arovas, D.P. Arovas, J. Custers, J. Gan, J. Gan, J. Gan, J. Hopkinson, J.L. Tallon, N. Read, N. Read, O. Parcollet, O. Trovarelli, P. Coleman, P. Coleman, P. Coleman, P. Coleman, P. Coleman, P. Coleman, P. Coleman, S.E. Barnes, S.E. Barnes, T.K. Ng   +35 more
core   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Pomen in obseg oznak za jezikovne različice v okviru informacijske tehnologije

Jezikoslovni zapiski, 2015
Najprej so predstavljena različna merila in obsegi jezikovnih kod, ki so registrirane pri ISO 639-1, 639-2, 639-3 in 639-6. Potem sta predstavljena RFC 5646 in 4647, kar naj bi razložilo, kako se lahko oblikujejo pravilne oznake za jezikovne različice ...
Han Steenwijk
doaj   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, EarlyView.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source

"Jolted into Submission": Masters and Slaves in Paul Auster’s The Music of Chance and Mr. Vertigo [PDF]

Polish Journal of English Studies
In Paul Auster’s The Music of Chance and Mr. Vertigo, characters who resemble free individuals turn into slaves. In both novels, the major characters find meaning in life by willingly submitting to a superior power.
Nahid Fakhrshafaie , Jalal Sokhanvar
doaj  

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Dene traditional knowledge about caribou cycles in the Northwest Territories

Rangifer, 2012
This paper is about what I have learned about the caribou cycle over the past one hundred and ten years or so, talking to Denesųłıné elders in Fort Resolution, Łutselk’e, and Yellowknife.
Danny Beaulieu
doaj   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, EarlyView.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source