Results 101 to 110 of about 7,281,051 (191)

Single‐cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease

iMeta, Volume 4, Issue 6, December 2025.
A clinical study reported that Abelmoschus manihot (L.) Medic (A. manihot), in the form of Huangkui capsule (HKC), combined with irbesartan (IRB) is an effective therapy for patients with diabetic kidney disease (DKD). The bioactive components of HKC are total flavones extracted from A. manihot (TFA).
Chenhua Wu, Haitao Tang, Yihong Yu, Yuhui Song, Haitao Ge, Yiming Shen, Jie Wu, Harvest F. Gu   +7 more
wiley   +1 more source

Renal phosphate handling in Gitelman syndrome—the results of a case-control study [PDF]

, 2018
Background: Patients with Gitelman syndrome, a hereditary salt-wasting tubulopathy, have loss-of-function mutations in the SLC12A3 gene coding for the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule.
Albisetti, Walter, Amoruso, Chiara, Barretta, Francesco, Bettinelli, Alberto, Bianchetti, Mario, Minnici, Giuseppe, Syrèn, Marie-Louise, Viganò, Cristina   +7 more
core  

Antagonistic regulation of parvalbumin expression and mitochondrial calcium handling capacity in renal epithelial cells [PDF]

, 2015
Parvalbumin (PV) is a cytosolic Ca²⁺-binding protein acting as a slow-onset Ca²⁺ buffer modulating the shape of Ca²⁺ transients in fast-twitch muscles and a subpopulation of neurons. PV is also expressed in non-excitable cells including distal convoluted
Henzi, Thomas, Schwaller, Beat
core   +3 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

KoVariome: Korean National Standard Reference Variome database of whole genomes with comprehensive SNV, indel, CNV, and SV analyses [PDF]

, 2018
High-coverage whole-genome sequencing data of a single ethnicity can provide a useful catalogue of population-specific genetic variations, and provides a critical resource that can be used to more accurately identify pathogenic genetic variants.
A McKenna, A Scally, A Telenti, AA Alshatwi, B Charlesworth, C Dong, C Genomes Project, C Loveday, D Hong, D Lakich, D Pinto, D Welter, DE Reich, DG MacArthur, DI Boomsma, EM Shore, FS Collins, GH Perry, H Li, H Stefansson, HP-AS Consortium, J Huddleston, J Jakobsson, J Wang, JI Kim, JR MacDonald, K Chen, K Ye, L Feuk, LP Wong, LT Chen, M Lek, M Nagasaki, MC Hunt, MJ Bamshad, MJ Landrum, ML Bondeson, P Cingolani, P Kraft, PH Sudmant, PH Sudmant, R Ihaka, R Redon, RE Mills, S Besenbacher, S Lee, S Malik, S Purcell, S Tunaru, SA McCarroll, SH Kwak, SM Ahn, ST Sherry, T Mimori, TL Yang, V Boeva, W Zhang, X Wang, YS Cho, YS Ju   +59 more
core   +2 more sources

Gene expression and functional annotation of the human and mouse choroid plexus epithelium [PDF]

, 2013
Background: The choroid plexus epithelium (CPE) is a lobed neuro-epithelial structure that forms the outer blood-brain barrier. The CPE protrudes into the brain ventricles and produces the cerebrospinal fluid (CSF), which is crucial for brain homeostasis.
Bergen, A.A.B. (Arthur), Brink, J.B. (Jacoline) ten, Essing, A.H.W. (Anke), Gorgels, T.G.M.F. (Theo), Jansonius, N.M. (Nomdo), Janssen, S.F. (Sarah), Spek, P.J. (Peter) van der, Spek, S.J.F. (Sophie) van der   +7 more
core   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia [PDF]

, 2017
Background Magnesium (Mg2+) is an essential ion for cell growth, neuroplasticity and muscle contraction. Blood Mg2+ levels
Bindels, René J.M., Dahan, Karin, de Baaij, Jeroen H.F., Devuyst, Olivier, Dorresteijn, Eiske M., Hennekam, Eric A.M., Hoenderop, Joost G.J., Kamsteeg, Erik-Jan, Knoers, Nine V.A.M., Meijer, Rowdy, Muller, Michelle, van den Dorpel, Marinus A.   +11 more
core  

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs [PDF]

, 2014
© 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.BACKGROUND: Cardiovascular ...
Ahmetaj-Shala, Blerina, Al'Yamani, Malak, Armstrong, Paul C. J., Kirkby, Nicholas S., Knowles, Rebecca, Leiper, James, Mackenzie, Louise, Mazi, Sarah, Mitchell, Jane A., Nüsing, Rolf M., Tomlinson, James A. P., Tucker, Arthur T., Wang, Zhen, Warner, Timothy D.   +13 more
core   +4 more sources

Identification of novel compound mutations of SLC12A3 gene in a Chinese pedigree with Gitelman's syndrome exhibiting Bartter's syndrome-liked phenotypes

, 2020
Background Gitelman's syndrome (GS) is a rare salt-losing renal tubular disorder associated with SLC12A3 gene mutations, which encodes the Na-Cl co-transporter (NCCT).
B. Dong, Chen Ying, Xinying Liu, Yangang Wang, W. Fang, Yuhang Zhao, Xiaofang Sun, W. Zhao   +7 more
semanticscholar   +1 more source