Results 71 to 80 of about 2,527,901 (173)

Putative Genomic Signatures of Local Adaptation in Five Local Indonesian Sheep Reveal Selection on Immunity, Reproduction, and Production Traits

Ecology and Evolution, Volume 16, Issue 6, June 2026.
We determined the genetic structure and signatures of selection in five local Indonesian sheep breeds using genome‐wide SNP data. By integrating population structure analyses with runs of homozygosity and haplotype‐based selection scans, we identified breed‐specific genomic regions associated with immunity, reproduction, pigmentation, metabolism, and ...
Putri Kusuma Astuti, Alexandru Eugeniu Mizeranschi, Herdis Herdis, Pradita Iustitia Sitaresmi, Alek Ibrahim, Sigit Prastowo, Nuzul Widyas, Tristianto Nugroho, Szilvia Kusza   +8 more
wiley   +1 more source

Integrative Bioinformatics Analysis Reveals COL13A1 and COL23A1 as Potential Diagnostic and Prognostic Biomarkers in Thyroid Cancer

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Thyroid cancer, the most prevalent endocrine malignancy globally, poses challenges owing to the limited understanding of its molecular drivers. Previous research has highlighted collagen genes, such as COL13A1 and COL23A1, as key players in thyroid cancer.
Md. Wahidul Islam, Md. Minhajur Rahman, Homaira Naznin, Md. Shohel Hossain, Tahmina Akter, Zayeda Akter Shatabde, Md. Jubayer Hossain   +6 more
wiley   +1 more source

Molecular studies in autosomal recessive deafness: the role of SLC26A4 gene.

, 2013
Mutações no gene SLC26A4 estão relacionadas a dois distúrbios de herança autossômica recessiva, a síndrome de Pendred (SP) e uma forma de surdez não sindrômica (DFNB4).
Nonose, Renata Watanabe, Renata Watanabe Nonose   +1 more
core   +1 more source

Estrogen receptor β regulates sex‐dependent airway mechanics and inflammation in a murine model of allergen exposure

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Sex differences in asthma severity have been reported; however, the specific contribution of estrogen receptor β (ERβ) remains incompletely defined. We tested the hypothesis that ERβ modulates sex‐specific physiological responses to chronic allergen exposure using C57BL/6J wild‐type (WT) and ERβ‐deficient (Esr2−/−) male and female mice ...
Carolyn Damilola Ekpruke, Dustin Rousselle, Maksat Babayev, Omar Borges‐Sosa, Rachel Alford, Lyidia Dinwiddie, David Michael Merritt, Christopher Michael Hemmerich, Douglas B. Rusch, Sarah Bradley, Matthew Louis Retzner, Erik Parker, Patricia Silveyra   +12 more
wiley   +1 more source

Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley   +1 more source

Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

Advanced Sensor Research, Volume 5, Issue 4, April 2026.
Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically examines current therapeutic strategies for sensorineural hearing loss, including traditional drug and physical therapies as well as emerging stem cell and gene therapies, providing a ...
Ruirui Chen, Yang Zhang, Zhe Li, Renjie Chai   +3 more
wiley   +1 more source

Role of Hearing Loss Genes in the Sensory Epithelia Associated With Meniere Disease

Sensory Neuroscience, Volume 2, Issue 1, March 2026.
ABSTRACT Meniere disease (MD) is an inner ear disorder characterized by episodic vertigo, tinnitus, fluctuating sensorineural hearing loss (SNHL), and aural fullness. Its hallmark pathological feature is endolymphatic hydrops. MD shows significant familial clustering in European and East Asian populations, supporting a strong genetic component in ...
Jose A. Lopez‐Escamez, Qiuyue Mao, Patricia Perez‐Carpena   +2 more
wiley   +1 more source

Branchial localization of acid (A‐type) and base (B‐type) excreting ionocytes in Amazonian stenohaline freshwater Potamotrygon ray

Journal of Fish Biology, Volume 108, Issue 3, Page 922-931, March 2026.
Abstract The branchial epithelium of Potamotrygon—a member of the only strictly freshwater elasmobranch family Potamotrygonidae—was observed via immunohistochemistry, and two distinct forms of ionocytes were identified. The acid (A‐type) and base (B‐type) secreting cells with respective basolateral–apical localizations of Na+/K+‐ATPase–Na+/H+ exchanger
M. W. Rossi, C. M. Wood, A. L. Val, J. M. Wilson   +3 more
wiley   +1 more source

Mouse Models for Pendrin-Associated Loss of Cochlear and Vestibular Function

Cellular Physiology and Biochemistry, 2013
The human gene SLC26A4 and the mouse ortholog Slc26a4 code for the protein pendrin, which is an anion exchanger expressed in apical membranes of selected epithelia.
Philine Wangemann
doaj   +1 more source

Effects of cAMP and CFTR modulation on apical fluid pH in human airway Calu‐3 cells

Physiological Reports, Volume 14, Issue 3, February 2026.
Abstract The airway epithelium serves as the first line of defense against inhaled insults present in the external environment by acting as a physical barrier and through host defense mechanisms. Proper maintenance of these host defense mechanisms relies on the regulation of airway surface liquid (ASL) composition and properties, a process that is ...
Jenny P. Nguyen, Nadia Milad, Jeremy A. Hirota   +2 more
wiley   +1 more source