Development of an IL-17A DNA Vaccine to Treat Systemic Lupus Erythematosus in Mice
Vaccines, 2020 The interleukin-17 (IL-17) family, especially IL-17A, plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). This study developed an IL-17A epitope vaccine to treat SLE in NZBWF1 and MRL/lpr mouse models.
Hiroshi Koriyama +6 more
doaj +1 more source
Prevalence of vascular disease in systemic lupus erythematosus compared with type-1 diabetes mellitus: a cross-sectional study of two cohorts. [PDF]
, 2015 OBJECTIVES Systemic lupus erythematosus (SLE) is associated with considerable cardiovascular morbidity that has not yet been directly compared with other diseases with known cardiovascular risk.
Ribi, Camillo +15 more
core +1 more source
ICF Core Sets: how to specify impairment and function in systemic lupus erythematosus [PDF]
, 2006 The World Health Organization’s International Classification of Function (ICF) is a tool to characterize and illuminate better the full of array of problems a patient faces when affected by disease.
Pisetsky, D.S. +7 more
core +1 more source
Indian Journal of Ophthalmology. Case Reports, 2023 Systemic lupus erythematosus (SLE) can have various ophthalmic manifestations, of which a rare but serious association is peripheral ulcerative keratitis (PUK), which can progress to corneal melt and perforation.
Sujatha Mohan +3 more
doaj +1 more source
Drivers of sustainable intensification in Kenyan rural and peri-urban vegetable production
International Journal of Agricultural Sustainability, 2018 Sustainable intensification promotes environmentally sound and productive agriculture. However, use of sustainable intensification practices (SIPs) is low in many sub-Sharan African countries.
Barnabas K. Kurgat +6 more
doaj +1 more source
Pregnancy outcomes in patients with systemic lupus erythematosus hospitalized in Imam Reza teaching hospital (Kermanshah, Iran) [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2019 Introduction: Systemic lupus erythematosus (SLE) is a common autoimmune disease and predominantly affects fertile women. This disease is associated with multisystem involvement and has high risk for both the mother and the fetus.
Anisodowleh Nankali +3 more
doaj +1 more source
Emergency situations in rheumatology with a focus on systemic autoimmune diseases
Biomedical Papers, 2016 Background and Aim. Rheumatic diseases are commonly considered chronic conditions. However, acute manifestations can be very severe and represent a diagnostic problem.
Jiri Vymetal +6 more
doaj +1 more source
Current Rheumatology Reports, 2017 Systemic lupus erythematosus is a severe autoimmune/inflammatory condition of unknown pathophysiology. Though genetic predisposition is essential for disease expression, risk alleles in single genes are usually insufficient to confer disease. Epigenetic dysregulation has been suggested as the missing link between genetic risk and the development of ...
openaire +3 more sources
The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus [PDF]
, 2003 In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high ...
Stott, DI +11 more
core +1 more source
T-lymphocyte subsets (CD3+, CD4+, and CD8+) in Systemic Lupus Erythematosus (SLE): Correlation with Clinical Manifestation [PDF]
Journal of Bioscience and Applied Research, 2021 AIM: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that has a multifactorial etiology. T- Lymphocytes are essential in SLE pathogenesis. It plays a crucial role in autoantibody production and the subsequent immune complex formation,
Abeer El-Maghraby +6 more
doaj +1 more source