NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
Long‐Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays
This study introduces a behavioral paradigm for memory updating and reveals underlying hippocampal mechanisms. Replays of place cells predict future behavioral choices during behavior and show a bias toward high‐reward locations during non‐rapid eye movement (NREM) sleep, specifically within the memory updating process.
Jifu Tong +14 more
wiley +1 more source
Association of sleep and glycaemic status with all-cause mortality: a prospective cohort study. [PDF]
Xu A +8 more
europepmc +1 more source
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju +11 more
wiley +1 more source
Better sleep is associated with improved mobility in adults: a scoping review. [PDF]
Siengsukon C +7 more
europepmc +1 more source
Upper airway imaging and function in obstructive sleep apnea in people with and without HIV
Chantal Darquenne +7 more
openalex +2 more sources
Sleep Dynamics Beyond Traditional Sleep Macrostructure [PDF]
PLAZZI, GIUSEPPE, PIZZA, FABIO
openaire +2 more sources
Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li +7 more
wiley +1 more source
Unrecognised sleep disturbances in patients with cirrhosis diagnosed with a portable electroencephalogram device. [PDF]
Uchiyama A +13 more
europepmc +1 more source

