Results 41 to 50 of about 1,143,306 (316)

Effects of alcohol on sleep parameters of sleep-deprived healthy volunteers

, 1997
Both partial and total sleep deprivation frequently result in a rebound of paradoxical sleep (PS), as well as of slow-wave or delta sleep. Acute administration of ethanol inhibits PS in normal volunteers.
Lobo, Leticia L. [UNIFESP], Sergio Tufik, Tufik, Sergio [UNIFESP], Letícia L. Lobo   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Numerical modelling of flow and transport in rough fractures

Journal of Rock Mechanics and Geotechnical Engineering, 2014
Simulation of flow and transport through rough walled rock fractures is investigated using the lattice Boltzmann method (LBM) and random walk (RW), respectively.
Scott Briggs, Bryan W. Karney, Brent E. Sleep   +2 more
doaj   +1 more source

Core Body and Skin Temperature in Type 1 Narcolepsy in Daily Life; Effects of Sodium Oxybate and Prediction of Sleep Attacks

, 2016
STUDY OBJECTIVES Previous laboratory studies in narcolepsy patients showed altered core body and skin temperatures, which are hypothesised to be related to a disturbed sleep wake regulation.
Reijntjes, Robert H. A. M., Donjacour, C E H M, Donjacour, Claire E H M, Reijntjes, Robert H A M, Van Someren, E J W, Van Someren, Eus J W, Baumann, Christian R., Fronczek, Rolf, Lammers, G J, Baumann, C R, Donjacour, Claire E. H. M., Van Someren, Eus J. W., Lammers, Gert Jan, Fronczek, R, Werth, Esther, van der Heide, A, Baumann, Christian R, van der Heide, Astrid, Werth, E; https://orcid.org/, Reijntjes, R H A M   +19 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Further validation of actigraphy for sleep studies

, 2003
Study Objectives: Actigraphy is generally compared to polysomnography (PSG), which has been considered the gold standard for sleep studies. The objective of the present study was to evaluate the concordance between PSG and two previously proposed ...
Sergio Tufik, Calil, Helena Maria [UNIFESP], Maria Laura Nogueira Pires, Helena Maria Calil, Tufik, Sergio [UNIFESP], Benedito-Silva, Ana Amélia [UNIFESP], Luciane de Souza, Souza, Luciane de [UNIFESP], Poyares, Dalva [UNIFESP], Dalva Poyares, Pires, Maria Laura Nogueira [UNIFESP], Ana Amélia Benedito-Silva   +11 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study [PDF]

Journal of Innovative Optical Health Sciences, 2014
In obstructive sleep apnea syndrome (OSA) the periodic reduction or cessation of breathing due to narrowing or occlusion of the upper airway during sleep leads to an impaired cerebral vascular autoregulation that is associated with an increased ...
Zhongxing Zhang, Maja Schneider, Ursula Fritschi, Isabella Lehner, Ramin Khatami   +4 more
doaj   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source