Results 221 to 230 of about 180,645 (290)

The real‐world relationship between naltrexone/bupropion treatment and weight loss in Canada: A retrospective chart review

open access: yesClinical Obesity, Volume 15, Issue 2, April 2025.
Summary This study examined the change in weight at 6 months of naltrexone/bupropion (NB), a combination pharmacological therapy for weight management, in real‐world practice in Canada. The study was conducted through an observational, retrospective, single‐arm chart review of adult patients who attended the Wharton Medical Clinic in Ontario, Canada ...
Sean Wharton   +4 more
wiley   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

open access: yesCell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang   +12 more
wiley   +1 more source

Non‐epileptic paroxysmal events in Rett syndrome: A systematic review of case‐based and observational evidence

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
This systematic review identifies and categorizes the spectrum of non‐epileptic paroxysmal events in Rett syndrome. Respiratory disturbances, behavioural episodes, and motor events were the most commonly reported. Improving clinician awareness and diagnostic clarity is key to avoiding unnecessary treatment and enhancing quality of life for individuals ...
Natasha Bhatti, Daniel E. Lumsden
wiley   +1 more source

Reallocating morning physical activity to later‐day activity and its association with type 2 diabetes incidence: The Maastricht Study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims The timing of physical activity may influence metabolic health through interactions with circadian rhythms, yet its role in type 2 diabetes mellitus (T2DM) development is unclear. We investigated associations between time‐of‐day‐specific physical activity and incident T2DM, and whether theoretically reallocating activity from morning to ...
Marvin Y. Chong   +8 more
wiley   +1 more source

Obstructive sleep apnea in children: prevalence and association with overweight and obesity. [PDF]

open access: yesFront Sleep
Ingolfsdottir I   +7 more
europepmc   +1 more source

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