Results 241 to 250 of about 233,764 (324)

Clinical and Molecular Characterization of Xia–Gibbs Syndrome: Expanding the Phenotypic Spectrum in a Brazilian Cohort

Clinical Genetics, EarlyView.
We present a clinical and molecular characterization of 16 Brazilian individuals with Xia–Gibbs syndrome, identifying 12 novel AHDC1 variants and four phenotypes not previously associated. Our findings support existing genotype–phenotype associations and suggest a new relation, expanding the known phenotypic and genetic spectrum of the syndrome ...
Maísa Ganz Sanchez Sennes, Laura Machado Lara Carvalho, Matheus Augusto Araújo Castro, Giovana Manilli Toccoli, Sofia de Oliveira Farias, Davi Mendes Campo Fialho, Eny Maria Goloni Bertollo, Erika Cristina Pavarino, Larissa Sampaio de Athayde, Cecilia Barbosa Buck, Maria Betânia Pereira Toralles, Maria Isabel Melaragno, Mariluce Riegel‐Giugliani, Gustavo Marquezani Spolador, Paulo Alberto Otto, Caroline Brandão Piai, Fernando Kok, Ceres Schmitz Cechella, Carla Rosenberg, Juan Clinton Llerena, Débora Romeo Bertola, Salmo Raskin, Chong Ae Kim, Ana Cristina Victorino Krepischi   +23 more
wiley   +1 more source

Multicenter clinical trial for the treatment of obstructive sleep apnea with a non-permanent orthodontic intraoral device in children. [PDF]

Eur J Pediatr
Kushida CA, Stevens J, Bennett M, Heit T, Klemp D, Raio D, Cozean J, Cozean C.   +7 more
europepmc   +1 more source

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet, Iain K. Robertson, Sharon P. Luccisano, Michelle L. Kilpatrick   +3 more
wiley   +1 more source

A comparative study on the hemodynamic effects of initiating positive airway pressure treatment in patients with obstructive and central sleep apnea. [PDF]

Sleep Breath
Müller C, Kerl J, Dellweg D.
europepmc   +1 more source

The real‐world relationship between naltrexone/bupropion treatment and weight loss in Canada: A retrospective chart review

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary This study examined the change in weight at 6 months of naltrexone/bupropion (NB), a combination pharmacological therapy for weight management, in real‐world practice in Canada. The study was conducted through an observational, retrospective, single‐arm chart review of adult patients who attended the Wharton Medical Clinic in Ontario, Canada ...
Sean Wharton, Elham Kamran, Lehana Thabane, Peter Yin, Rebecca Christensen   +4 more
wiley   +1 more source

A Possible Missing Link Between Obstructive Sleep Apnea Syndrome (OSA) Associated with Tobacco Use and Inflammation Biomarkers. [PDF]

Healthcare (Basel)
Pintilie AL, Zabara Antal A, Ciuntu BM, Toma D, Tiron R, Stirbu R, Zabara ML, Crisan Dabija R.   +7 more
europepmc   +1 more source

Estimating the association and timing of occurrence between obesity and related comorbidity outcomes in a real‐world setting: A cohort study in the United States

Clinical Obesity, EarlyView.
Estimating the Association and Timing of Occurrence between Obesity and Related Comorbidity Outcomes in a Real‐World Setting: A Cohort Study in the United States. An observational, retrospective cohort study of adults with available body mass index (BMI) data during the period 2010–2019 in a large United States claims‐linked electronic health records ...
Firas Dabbous, Jigish Bhavsar, Jayashri Desai, Anthony Fabricatore, Bríain Ó. Hartaigh, Wojciech Michalak, Sariya Udayachalerm, Cynthia Saiontz‐Martinez, Zhenxiang Zhao, Fatima Cody Stanford   +9 more
wiley   +1 more source

Tirzepatide and health‐related quality of life in adults with obesity or overweight: Results from the SURMOUNT‐3 phase 3 randomized trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Tirzepatide reduced weight significantly more than placebo in adults with obesity/overweight who had already achieved ≥5% weight reduction with a 12‐week intensive lifestyle intervention (randomized population) in SURMOUNT‐3, a phase 3, 72‐week, randomized, double‐blind clinical trial.
Theresa Hunter Gibble, Dachuang Cao, Tammy Forrester, Julia Fraseur Brumm, Ariana M. Chao   +4 more
wiley   +1 more source

Screening for Obstructive Sleep Apnea Among the Adult Population in the Northeastern Region of Romania. [PDF]

Dent J (Basel)
Tanellari O, Alushi A, Toti C, Balcos C, Armencia AO, Panaite T, Zetu I.   +6 more
europepmc   +1 more source

Obstructive sleep apnea is associated with impaired insulin clearance and hepatic insulin sensitivity in paediatric obesity

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obstructive sleep apnea (OSA) affects up to 40% of children and adolescents with obesity and is linked to hyperinsulinism. However, the mechanisms underpinning this association remain unclear. The study aims to assess the three key determinants of hyperinsulinemia: insulin clearance, secretion, and sensitivity in paediatric patients with ...
Giuseppina Rosaria UMANO, Francesca Aiello, Giulia Rondinelli, Alessandra Salvati, Delfina Petrone, Maria Vittoria Sibillo, Raffaella D'Ausilio, Pierluigi Marzuillo, Anna Grandone, Grazia Cirillo, Domenico Tricò, Emanuele Miraglia del Giudice   +11 more
wiley   +1 more source