Results 201 to 210 of about 556,046 (307)

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao, Xiaohui Zhang, Peng Lu, Qiang Wang   +3 more
wiley   +1 more source

Outcomes for Frail Dialysis Patients Not Referred for Transplantation: A Cohort Study

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Frailty is highly prevalent in kidney failure, but it is unclear whether frailty impacts health outcomes for those initiating dialysis who are not referred for transplantation. Our objective was to determine if frailty is associated with death or development of a permanent contraindication to transplantation among eligible non ...
Joshua Goodwin, Jordan Thorne, Amanda Vinson, David Clark, Bryce Kiberd, Micheal Sun, Karthik Tennankore   +6 more
wiley   +1 more source

MAD vs. AHI: Sleep patterns, oxygenation among polysomnography diagnosed by OSA patients. [PDF]

Lung India
Varshan LBP, Ayub II, Balasundaram S.
europepmc   +1 more source

Treatment of Central Sleep Apnea Syndromes [PDF]

Sleep, 2012
Ramar K, Aurora R, Chowdhuri S, Bista S, Casey K, Lamm C, Kristo D, Mallea J, Rowley J, Zak R, Tracy S.   +10 more
europepmc   +1 more source

Validation of a deep learning-based system for sleep staging, arousal detection, and respiratory event scoring in atrial fibrillation patients. [PDF]

J Clin Sleep Med
Sousa S, Teixeira C, Sigmarsdóttir T, Finnsson E, Ágústsson J, Sigþórsson S, Bjarkason S, Drummond M, Bugalho A.   +8 more
europepmc   +1 more source

Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling, Lena Marth, Katja Sandkühler, Anna Stockbauer, Elisabeth Wlasich, Alexander Jäck, Olivia Wagemann, Julia Kustermann, Steffen Halbgebauer, Hayrettin Tumani, Günter Höglinger, Johannes Levin   +11 more
wiley   +1 more source

Salivary Aldosterone as a Biomarker for Obstructive Sleep Apnea: Diagnostic Performance and the Moderating Role of Mean Arterial Pressure-A Cross-Sectional Study. [PDF]

Clocks Sleep
Chen Z, Lau MN, Tengku Hamzah TNN, Abd Rahman ANA, Goh LC, Wey MC.   +5 more
europepmc   +1 more source

Down Syndrome and Alzheimer's Disease: A Qualitative Study Exploring Understanding and Perceptions of Dementia and Diagnostic Pathways Among People With Down Syndrome and Their Families

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background People with Down syndrome are at high risk of Alzheimer's disease. Dementia diagnosis and support are a growing challenge for health and social care systems. There is limited knowledge of the perceptions of dementia and dementia diagnostic pathways among people with Down syndrome and their families.
M. L. Healy, A. Brodtmann, A. M. Foster, D. Ayton   +3 more
wiley   +1 more source

Diagnostic Performance of a Combined Reflective Photoplethysmography and Ultra-Wideband Radar Device for Obstructive Sleep Apnea: Comparison with Polysomnography. [PDF]

Nat Sci Sleep
Qiao M, Zhang H, Yuan L, Huang Y, Zhang Q, Pan S, Xu L, Fu C, Yu H.   +8 more
europepmc   +1 more source

Psychometric properties of the Ekman 60‐Faces Test in clinical populations: A systematic review and meta‐analysis

Journal of Neuropsychology, EarlyView.
Abstract The Ekman 60‐Faces Test is widely used to assess facial emotion recognition, but information on its validity and reliability is scarce. This systematic review evaluated the reporting of psychometric properties across clinical populations. A total of 159 studies (n = 5978) were included: case–control (n = 109), single cohort (n = 37) and review/
Linde Assendelft, Jackie M. Poos, Esther van den Berg   +2 more
wiley   +1 more source