Results 81 to 90 of about 43,382 (283)

Unraveling the Link between Sleep Disturbances and Parkinson’s Disease: A Narrative Review

Acta Neurologica Taiwanica
Parkinson’s disease (PD) is characterized by both motor and nonmotor symptoms, many of which originate from the pathophysiology of the disease and its progression.
Omar Cardenas-Saenz, Fátima Gabriela Macias-Ortiz, Naomi Nazareth Becerra-Aguiar, Susana María de los Angeles Sainz-del Real, Patricia Orozco-Puga, Azyadeh Camacho-Ordoñez, Mayela de Jesus Rodriguez-Violante   +6 more
doaj   +1 more source

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

A Study of Sleep Architecture among Sleep Apnea Patients at a Tertiary Care Center: A Retrospective Analysis

, 2023
Keyur Patel, Parth Dineshbhai Patel, Dhruminkishan A Prajapati, Deepali J. Kamdar   +3 more
openalex   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Sleep architecture and vitamin D in hypertensives with obstructive sleep apnea: A polysomnographic study [PDF]

, 2023
Justyna Kanclerska, Mieszko Wickiewicz, Dorian Nowacki, Anna Szymańska–Chabowska, Rafał Poręba, Grzegorz Mazur, Helena Martynowicz   +6 more
openalex   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivation

Neurobiology of Sleep and Circadian Rhythms
Rett syndrome (RTT) is a severe, progressive neurodevelopmental disorder caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MECP2).
Abrar Al Maghribi, Caitlin Ottaway, Michael Rempe, Elizabeth Medina, Kaitlyn Ford, Kristan Singletary, Lucia Peixoto   +6 more
doaj   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

The Impact of Lunch Timing on Nap Quality

Clocks & Sleep
Purpose: Previous research has established that food intake is a biological regulator of the human sleep–wake cycle. As such, the timing of eating relative to sleep may influence the quality of sleep, including daytime naps.
Jennifer E. Fudge, Emily T. Peterson, Shae-Lynn M. Koe, Hans C. Dringenberg   +3 more
doaj   +1 more source