Results 101 to 110 of about 205,740 (293)

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Sleep deprivation suppresses aggression in Drosophila

eLife, 2015
Sleep disturbances negatively impact numerous functions and have been linked to aggression and violence. However, a clear effect of sleep deprivation on aggressive behaviors remains unclear.
Matthew S Kayser, Benjamin Mainwaring, Zhifeng Yue, Amita Sehgal   +3 more
doaj   +1 more source

Sleep-like slow oscillations improve visual classification through synaptic homeostasis and memory association in a thalamo-cortical model

, 2019
The occurrence of sleep passed through the evolutionary sieve and is widespread in animal species. Sleep is known to be beneficial to cognitive and mnemonic tasks, while chronic sleep deprivation is detrimental.
Capone, Cristiano, Golosio, Bruno, Paolucci, Pier Stanislao, Pastorelli, Elena   +3 more
core   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated with Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, Accepted Article.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA), and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serological markers. Methods We analyzed serum and plasma from three cohorts: pre‐symptomatic individuals who later developed ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source

Isoflurane anesthesia and sleep deprivation trigger delayed and selective sleep alterations

Scientific Reports
Isoflurane anesthesia (IA) partially compensates NREM sleep (NREMS) and not REM sleep (REMS) requirement, eliciting post-anesthetic REMS rebound. Sleep deprivation triggers compensatory NREMS rebounds and REMS rebounds during recovery sleep as a result ...
Leesa Joyce, Clara Carrillo Mas, Veronica Meedt, Matthias Kreuzer, Gerhard Schneider, Thomas Fenzl   +5 more
doaj   +1 more source

If you don’t snooze you lose health and gain weight: evidence from a regression discontinuity design [PDF]

, 2015
Sleep deprivation is increasingly recognized as a public health challenge. While several studies provided evidence of important associations between sleep deprivation and health outcomes, it is less clear whether sleep deprivation is a cause or a marker ...
Giuntella, Osea, Mazzonna, Fabrizio
core  

The veterinarian as educator: Experiences undertaking an anatomy education extra mural studies placement

Anatomical Sciences Education, EarlyView.
Abstract Educating clients and teaching and mentoring colleagues are crucial yet underappreciated elements of a veterinarian's professional duties. Unfortunately, veterinary curricula rarely explicitly aim to encourage students to develop effective teaching practices.
Renato L. Previdelli, Emma Driver, Jane Tomlin, Sarah B. Channon   +3 more
wiley   +1 more source

Comparison of examination performance and test anxiety during bell‐paced and self‐paced gross anatomy laboratory examinations

Anatomical Sciences Education, EarlyView.
Abstract Pacing during anatomy laboratory examinations may influence both student performance and test anxiety. This study compared bell‐paced (BP) and self‐paced (SP) timing structures to assess their impact on students' test performance, test anxiety, and pacing preferences.
Danielle C. Bentley, Angelo Sotto, Peter Lombardi   +2 more
wiley   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source