Results 151 to 160 of about 3,933,885 (384)

Gender differences dominate sleep disorder patients' body problem complaints [PDF]

, 1994
Ted L. Rosenthal, Elaine S. Bryant, Hélio Lemmi   +2 more
openalex   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals

Advanced Science, EarlyView.
Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang, Xue‐Jing Lu, Hui‐Juan Zhang, Zhao‐Xing Wei, Ya‐Zhuo Kong, Yi‐Heng Tu, Gian Domenico Iannetti, Li Hu   +7 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

The Relationship between Nocturnal Hypoxemia and Left Ventricular Ejection Fraction in Congestive Heart Failure Patients [PDF]

Background: sleep – disordered breathing ( SDB) is Frequently observed in Patients with Congestive heart Failure. This Study examines the Prevalence of sleep disorder in stable heart failure Patients regardless of ejection Fraction. Method: By Means of
زمانی, بیژن, فولادی, نسرین, مهدی نیا, فریبا, میرزا آقازاده, محمد   +3 more
core  

Common Neural Correlates for Subjective and Objective Sleepiness Indices: A Functional Connectivity Study

Nature and Science of Sleep
Yuki Motomura,1,2 Shingo Kitamura,1 Kentaro Oba,1,3 Ruri Katsunuma,1 Yuri Terasawa,1,4 Akiko Hida,1 Yoshiya Moriguchi,1,5 Kazuo Mishima1,6 1Department of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and ...
Motomura Y, Kitamura S, Oba K, Katsunuma R, Terasawa Y, Hida A, Moriguchi Y, Mishima K   +7 more
doaj  

Sleep‐Disordered Breathing in Alcoholics: Association with Age [PDF]

, 1993
Michael S. Aldrich, James E. Shipley, Rajiv Tandon, Phillip Kroll, Kirk J. Brower   +4 more
openalex   +1 more source

Closed‐Loop Bioelectronic Artificial Pancreas Patch for Continuous Monitoring and Regulation of Blood Glucose in Diabetic Rats and Pigs

Advanced Science, EarlyView.
A closed‐loop bioelectronic artificial pancreas patch is presented for glucose monitoring and regulation. Utilizing transiently dissolvable microneedle arrays integrated with microtube arrays, the patch efficiently delivers insulin into interstitial fluid, eliminating the need for external long needles. In diabetic pigs, it demonstrates excellent blood
Yiqun Liu, Changxi Zhang, Lingyi Xu, Yuan Ma, Yuanyuan Ma, Ying Chen, Difei Lu, Le Ye, Li Yang, Yue Cui   +9 more
wiley   +1 more source

HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer

Advanced Science, EarlyView.
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen   +13 more
wiley   +1 more source

The Double-edged Sword: A Mixed Methods Study of the Interplay between Bipolar Disorder and Technology Use [PDF]

, 2017
Human behavior is increasingly reflected or acted out through technology. This is of particular salience when it comes to changes in behavior associated with serious mental illnesses including schizophrenia and bipolar disorder.
Chang, Pamara, Doherty, Gavin, Gay, Geri K., Guha, Shion, Matthews, Mark, Murnane, Elizabeth, Snyder, Jaime   +6 more
core   +1 more source