Results 161 to 170 of about 3,933,885 (384)

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

open access: yesAdvanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang   +11 more
wiley   +1 more source

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

open access: yesAdvanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang   +11 more
wiley   +1 more source

Sleep disturbance and serum ferritin levels associate with high impulsivity and impulse control disorders in male Parkinson\u27s Disease patients [PDF]

open access: yes, 2017
Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk.
Anderton, R   +6 more
core   +1 more source

Precision‐Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart‐Warning of Weightlessness Induced Bone Loss

open access: yesAdvanced Science, EarlyView.
It is synthesized precision‐arranged DNA origami plasmonic nanoantennas for multiplexed and intelligent warning of bone loss induced by microgravity and radiation. The ordered nanoantennas simultaneously and accurately detected calcium ions, interleukin‐6, and microRNA‐214 in serum from mice exposed to microgravity and radiation, with performance ...
Yufan Ling   +14 more
wiley   +1 more source

Prevalence and Factors Associated with Rapid Eye Movement-Related Obstructive Sleep Apnea in Patients with Narcolepsy

open access: yesNature and Science of Sleep
Hamza O Dhafar,1 Ali A Awadh,2 Salih A Aleissi,1 Galal Eldin Abbas Eltayeb,3 Samar Z Nashwan,1 Ahmed S BaHammam1,4 1The University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Seha ...
Dhafar HO   +5 more
doaj  

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

open access: yesAdvanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen   +16 more
wiley   +1 more source

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