Results 151 to 160 of about 2,341,236 (258)

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Deep Learning for AD Risk Screening and Progression Prediction

Advanced Science, EarlyView.
A pretrained MRI‐based deep learning model generalizes from Western cohorts to an independent Chinese cohort, detects Alzheimer's disease with high sensitivity, and identifies elevated AD risk years before diagnosis. Its risk scores align with cognition and plasma biomarkers, and individualized brain risk maps uncover clinically distinct subtypes ...
Bin Lu, Yan‐Rong Chen, Rui‐Xian Li, Ming‐Kai Zhang, Shao‐Zhen Yan, Guan‐Qun Chen, Jing‐Hua Wang, Wen‐Hui Chai, Francisco Xavier Castellanos, Paul M. Thompson, Jie Lu, Ying Han, Chao‐Gan Yan   +12 more
wiley   +1 more source

Atopic Dermatitis and Sleep Disorders. [PDF]

Allergy Asthma Immunol Res
Bai G, Shao X, Ou Y, Chen J, Tan Z, Chen A, Zhang J.   +6 more
europepmc   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Impulsivity and sleep disorders in schoolchildren

, 2005
UNIFESP, Ctr Clin & Sci Sleep, Dept Neurol, Sao Paulo, SP, BrazilUNIFESP, Dept Internal Med, Sao Paulo, SP, BrazilUNIFESP, Ctr Clin & Sci Sleep, Dept Neurol, Sao Paulo, SP, BrazilUNIFESP, Dept Internal Med, Sao Paulo, SP, BrazilWeb of ...
Medeiros, Marilaine [UNIFESP], Silva, Tatiana Almeida [UNIFESP], Souza, Adriana [UNIFESP], Prado, Lucila Bizari Fernandes do [UNIFESP], Barreto, Luciane de Andrade [UNIFESP], Canepa, Rezinilda Portela Meira [UNIFESP], Ferreira, Vanessa Ruotolo [UNIFESP], Carvalho, Luciane Bizari Coin de [UNIFESP], Prado, Gilmar Fernandes do [UNIFESP]   +8 more
core  

Sleep disorders and cardiovascular diseases. [PDF]

Trends Open
Pan X, Hussain Y, Dar MI.
europepmc   +1 more source

LFA‐1‐Engineered Extracellular Vesicles Deliver CD59 to Protect Endothelial Integrity in Acute Lung Injury

Advanced Science, EarlyView.
LFA‐1‐engineered extracellular vesicles preferentially target pulmonary endothelium and deliver CD59, thereby inhibiting membrane attack complex formation, preserving vascular integrity, and attenuating acute lung injury. This strategy reveals a targeted approach for protecting the pulmonary vasculature from complement‐mediated damage.
Yin Zhu, Shravani Etrouth, Payaningal R. Somanath, S. Priya Narayanan, Yutao Liu, Xiaoyun Wang, Duo Zhang   +6 more
wiley   +1 more source

Cardiovascular Implications of Sleep Disorders Beyond Sleep Apnea

Purpose of review: Sleep is crucial for human health and life. There is still limited attention to the association between sleep disorders beyond sleep apnea and cardiovascular (CV) health.
Maiolino, Giuseppe, Yoon, Jee-Eun, Kwon, Younghoon, Park, Jung-A, Pengo, Martino F., Lin, Gen-min, Liu, Xiaoyue, Chang, Yoonhee   +7 more
core   +1 more source

Dual‐Defect‐Engineered Zinc Oxynitride Thin‐Film Transistors Enabling Electrostatic Current Balancing in Geometrically Symmetric Oxide Logic

Advanced Electronic Materials, EarlyView.
Dual‐defect engineering controls subgap states in zinc oxynitride (ZnON) thin‐film transistors, yielding a field‐effect mobility of 26.58 cm2 V−1 s−1. A process‐associated threshold‐voltage shift is repurposed within a dual‐gate depletion‐mode load to electrostatically balance current in a geometrically symmetric NMOS inverter.
Seung Min Lee, Dong Hyeon Kim, Ji Won Woo, Dong Beom Lee, Kye Yeong Jo, Joo Hyun Jeong, Yun Hyeok Jeong, Joon Hwang, Sang Jik Kwon, Eou‐Sik Cho, Min‐Kyu Park   +10 more
wiley   +1 more source

Enhancing Elderly Health Through Physical Activities: Insights From a Global Bibliometric Review, 1900–2023

AGING MEDICINE, EarlyView.
Bibliometric analysis reveals rising global research on physical activity and elderly health, dominated by developed nations. Key hotspots include healthy aging, physical activity's mental health benefits, and VR exercise interventions. Promoting physical activity is vital for healthy aging, requiring greater technology integration and research from ...
Hongman Wang, Bo Xie, Can Liu, Yifan Song   +3 more
wiley   +1 more source