Results 201 to 210 of about 820,081 (239)

A prospective natural history study protocol for clinical trial readiness in synaptic disorders

Epilepsia, EarlyView.
Abstract Objective STXBP1‐related disorder (STXBP1‐RD) and SYNGAP1‐related disorder (SYNGAP1‐RD) are two common genetic synaptopathies that are associated with epilepsy, developmental delay, intellectual developmental disorder, and behavioral problems.
Jillian L. McKee, Sarah M. Ruggiero, Kristin Cunningham, JoeyLynn Coyne, Ian McSalley, Michael C. Kaufman, Bintou Bane, Torrey Chisari, Jonathan Toib, Carlyn Glatts, Sarah Tefft, Julie M. Orlando, Viveknarayanan Padmanabhan, Alexander K. Gonzalez, Alicia Harrison, Charlene Woo, Stephanie A. Zbikowski, Rency Dhaduk, Johanna Mercurio, Macie McCarthy, Jan H. Magielski, Zachary Grinspan, Megan Abbott, Juliet Knowles, Hsiao‐Tuan Chao, Katherine Xiong, Elizabeth Berry‐Kravis, Sepideh Tabarestani, J. Michael Graglia, Kathryn Helde, Virginie McNamar, Charlene Son Rigby, James Goss, Scott Demarest, Andrea Miele, Benjamin Prosser, Michael J. Boland, Samuel R. Pierce, Ingo Helbig   +38 more
wiley   +1 more source

A dermo-hypothalamic axis driven by TNF-α mediates sleep disturbances in psoriasis. [PDF]

Commun Biol
Chen D, Ma Y, Lu J, Xi X, Dai X, Zhang C, Diao Z, Guo X, Yin Z.   +8 more
europepmc   +1 more source

Psychological stress during wartime and its association with seizure‐related emergency department utilization

Epilepsia, EarlyView.
Abstract Objective Psychological stress is commonly reported as a seizure precipitant in epilepsy, yet evidence from major crises remains limited and inconsistent. We examined whether the October 2023 Israel–Hamas conflict affected acute seizure‐related healthcare utilization among adults with epilepsy. Methods We conducted a retrospective cohort study
Anda Eilam, Mahdi Arar, Yacov Balash, Volodymyr Samogalskyi, Merav Greenstein, Michael Zouari, Nadejda Khmelev   +6 more
wiley   +1 more source

Longitudinal evaluation of sleep disturbances in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. [PDF]

J Cancer Surviv
Daniel LC, Wang H, Brinkman TM, Ruble K, Zhou ES, Palesh O, Howell R, Mulrooney DA, Crabtree VM, Mostoufi-Moab S, Oeffinger K, Neglia J, Yasui Y, Armstrong GT, Krull K.   +14 more
europepmc   +1 more source

Atrial cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala, Monika Przewłocka‐Kosmala   +1 more
wiley   +1 more source

WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse

Epilepsia, EarlyView.
Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper, Zining Liu, Aristea S. Galanopoulou, Gernot Hlauschek, Benjamin Sinclair, Wai Lam Leung, Stefanie Dedeurwaerdere, Elisabeth Doran, Solomon L. Moshé, David C. Henshall, Ozlem Akman, Pablo M. Casillas‐Espinosa   +11 more
wiley   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Performance of an electroencephalography-measuring headband or actigraphy compared with polysomnography in older adults with sleep disturbances. [PDF]

Sleep
Miner B, Chen A, Pan Y, Cho G, Talarczyk J, Burzynski C, Polisetty L, Doyle M, Iannone L, Mejnartowicz S, Breier RA, Gill TM, Yaggi HK, Knauert M.   +13 more
europepmc   +1 more source

Seizure forecasting: The long and winding road to clinical translation

Epilepsia, EarlyView.
Abstract Seizure forecasting has progressed from theoretical aspiration to a rapidly advancing research domain, yet clinical translation remains limited. Over the past decades, advances in algorithm development, chronic electroencephalography (EEG), wearable sensors, and the characterization of seizure cycles have demonstrated that seizure risk is not ...
Philippa J. Karoly, Rachel E. Stirling, Mark J. Cook, Daniel M. Goldenholz, Maxime O. Baud, Vikram R. Rao, Solveig Vieluf, Benjamin H. Brinkmann   +7 more
wiley   +1 more source

Brain dynamic audio stimulation for subjective sleep disturbances in healthcare professionals: a single-arm pilot feasibility study. [PDF]

Front Neurosci
Lin HM, Ho MC, Zhong YL, Tsai CH, Hsieh WT.   +4 more
europepmc   +1 more source