Results 81 to 90 of about 49,883 (246)

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

A Phase 1 Study of Convection‐Enhanced Delivery of Intraputaminal AAV2‐GDNF in Advanced Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Neurotrophic therapeutic approaches have been limited in part by incomplete delivery to the putamen. We developed image‐guided convection‐enhanced delivery with real‐time monitoring to improve intraputaminal distribution of neurotrophic gene therapy. Objectives To
John D. Heiss, Debra J. Ehrlich, Codrin Lungu, Joseph Y. Choi, Gretchen Scott, Irene Dustin, Dima A. Hammoud, Peter Herscovitch, Russell R. Lonser, Kareem A. Zaghloul, Krystof Bankiewicz   +10 more
wiley   +1 more source

Fatigue in Myasthenia Gravis: Recent Advances and Emerging Concepts

Muscle &Nerve, EarlyView.
ABSTRACT Fatigue is a common, often disabling symptom in myasthenia gravis (MG), distinct from muscle fatigability, and strongly associated with reduced quality of life. This narrative review examines current evidence on fatigue in MG, its patient impact, and future research directions. Earlier studies, mostly small and heterogeneous, reported a highly
Yvonne J. M. Campman, Martijn R. Tannemaat, Annabel M. Ruiter, Sarah Hoffmann   +3 more
wiley   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Sleep hygiene and sleep quality as predictors of positive and negative dimensions of mental health in college students

Cogent Psychology, 2016
College students are one of the top at-risk groups for chronic sleep loss and poor sleep quality, which can yield deleterious effects on health. The college population is also notorious for poor sleep hygiene, or modifiable behaviors that promote ...
Hannah Peach, Jane F. Gaultney, David D. Gray   +2 more
doaj   +1 more source

Consensus‐Based Safety Recommendations for Informal Home Care: A Mixed Methods Study

Research in Nursing &Health, EarlyView.
ABSTRACT As home‐based care expands globally, informal caregivers are responsible for medical and nursing responsibilities, raising serious concerns about safety and risk management. This study proposes expert‐informed, safety recommendations tailored to informal caregiving in home settings.
Nida Abed, Vanessa Ribeiro Neves, Valerie Matarredona Perez, Daniel Monasor Ortola, Virginia Ferrer García, Bojana Knezevic, Paulo Sousa, Reinhard Strametz, Mercedes Guilabert, José Joaquín Mira   +9 more
wiley   +1 more source

The Technology Dependence Index (TDI): Development and Validation in Neonatal and Pediatric Populations

Research in Nursing &Health, EarlyView.
ABSTRACT The survival of infants and children with complex medical conditions continues to increase, underscoring the need to quantify technology dependence more effectively. Existing measures emphasize mortality risk and fail to capture the burden of ongoing technological support.
Ashlee J. Vance, Matthew Peterson, Hayley H. Estrem, Christine A. Fortney, Sharron L. Docherty, Debra H. Brandon   +5 more
wiley   +1 more source

SLEEP HYGIENE IN ADOLESCENTS

Pedagogic Research-Applied Literacy Journal
Adolescent health is crucial for developing a productive future generation, with sleep quality being a key component. Many adolescents struggle with sleep issues due to academic pressure, excessive gadget use, and poor habits. This community service project aimed to improve sleep hygiene awareness among students at MTS Ma'arif 2 Ajibarang through ...
null Iwan Purnawan, null Ikit Netra Wirakhmi   +1 more
openaire   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source