Results 131 to 140 of about 2,771,485 (258)
Exploration, EarlyView.The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu +18 more
wiley +1 more source
Char Layer Thickness Evolution During Structural Timber Fire Experiment and Final Density Profile
Fire and Materials, EarlyView.ABSTRACT This paper evaluates several non‐destructive experimental methods for determining the char layer thickness and its density profile in structural timber samples exposed to standard ISO 834 fire curve experiments. Microwave echo pulse, ultrasonic echo pulse, X‐ray computed tomography, and resistance drilling were evaluated.
Fernando Pérez Pérez +4 more
wiley +1 more source
FlexMat, EarlyView.Abstract Early diagnosis of hepatocellular carcinoma (HCC) remains challenging because conventional serum biomarkers, especially alpha‐fetoprotein (AFP), show limited sensitivity for early‐stage disease. Recent progress in engineered molecular diagnostics provides new opportunities to improve HCC detection through integrated material, molecular, and ...
Jingzhi Xue +5 more
wiley +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
iNew Medicine, EarlyView.ABSTRACT Objective Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer’s disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD ...
Xuerui Pang +8 more
wiley +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Type 2 diabetes (T2DM) heightens cognitive impairment risk, yet the mechanisms remain unclear. Hyperglycemia‐induced iron dysregulation in deep gray matter (DGM) nuclei may be a crucial mechanism. Purpose To investigate DGM iron deposition in T2DM using Quantitative Susceptibility Mapping (QSM) and determine its association with ...
Kun Wang +5 more
wiley +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Assessment of amyloid‐β (Aβ) burden and associated iron deposition and neurodegeneration is important for Alzheimer's disease (AD) management. Although quantitative susceptibility mapping (QSM) detects iron and myelin changes, conventional metrics suffer from signal cancelation between paramagnetic and diamagnetic components ...
Hiroyuki Tatekawa +14 more
wiley +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Long‐term blood pressure variability (BPV) is associated with cognitive decline, yet the underlying mechanisms have not been fully elucidated. Purpose To investigate the associations between long‐term BPV and hippocampal subfield volume and cognitive function and to assess the mediation effect of hippocampal subfield volume.
Fei Li +17 more
wiley +1 more source
A Quasi-residuals method in sliced inverse regression
An effective data-analytic tool, sliced inverse regression(SIR), for the analysis of multivariate data was developed by Li (Technical Report, Department of Mathematics, UCLA, 1989) and Duan and Li (J. Amer. Statist. Assoc. 86 (1991) 316).
Tian, Maozai, Li, Guoying
core
Confidence bands for inverse regression models with application to gel electrophoresis [PDF]
We construct uniform confidence bands for the regression function in inverse, homoscedastic regression models with convolution-type operators. Here, the convolution is between two non-periodic functions on the whole real line rather than between two ...
Bissantz, Nicolai +2 more
core